Controlled Cohort Study of Serum Gonadal and Adrenocortical Steroid Levels in Males Prior to Onset of Rheumatoid Arthritis (pre-RA): A Comparison to pre-RA Females and Sex Differences among the Study Groups

Table 2

Age-adjusted partial correlations of log-transformed hormones in male pre-RA (top) and CN (bottom)*.

	E2/TEST	OH-PREG	OH-P4	DHEA	ADIONE	TEST	E2	Cortisol	DHEAS	LH	PRL
E2/TEST
𝑟𝑝		−0.143	−0.355	−0.387	−0.377	−0.813	0.339	−0.234	0.127	0.163	0.404
𝑃		0.583	0.162	0.125	0.136	0.000	0.183	0.366	0.627	0.532	0.108
𝑛		18	18	18	18	18	18	18	18	18	18
OH-PREG
𝑟𝑝	−0.211		0.644	0.598	0.355	0.336	0.316	𝟎.𝟖𝟒𝟑^∗	0.076	0.056	0.120
𝑃	0.077		0.005	0.011	0.162	0.188	0.216	0.000	0.773	0.830	0.647
𝑛	72		18	18	18	18	18	18	18	18	18
OH-P4
𝑟𝑝	−0.281	0.724		0.440	0.559	0.539	0.267	0.496	−0.227	0.063	−0.123
𝑃	0.018	0.000		0.077	0.020	0.026	0.299	0.043	0.380	0.811	0.640
𝑛	72	72		18	18	18	18	18	18	18	18
DHEA
𝑟𝑝	−0.085	0.605	0.448		0.641	0.543	0.312	0.737	0.344	−0.211	−0.187
𝑃	0.482	0.000	0.000		0.006	0.024	0.223	0.001	0.177	0.417	0.472
𝑛	72	72	72		18	18	18	18	18	18	18
ADIONE
𝑟𝑝	0.051	0.507	0.611	0.651		0.467	0.129	0.471	−0.207	0.263	−0.202
𝑃	0.670	0.000	0.000	0.000		0.059	0.621	0.057	0.426	0.307	0.437
𝑛	72	72	72	72		18	18	18	18	18	18
TEST
𝑟𝑝	−0.718	0.420	0.508	0.278	0.293		0.228	0.454	−0.242	−0.073	−0.327
𝑃	0.000	0.000	0.000	0.019	0.013		0.379	0.067	0.349	0.781	0.200
𝑛	72	72	72	72	72		18	18	18	18	18
E2
𝑟𝑝	0.427	0.283	0.276	0.252	0.443	0.297		0.404	−0.052	0.152	0.141
𝑃	0.000	0.017	0.020	0.034	0.000	0.012		0.108	0.842	0.561	0.588
𝑛	72	72	72	72	72	72		18	18	18	18
Cortisol
𝑟𝑝	0.028	0.557	0.433	0.538	0.638	0.161	0.256		0.308	0.060	0.086
𝑃	0.817	0.000	0.000	0.000	0.000	0.179	0.031		0.229	0.818	0.741
𝑛	72	72	72	72	72	72	72		18	18	18
DHEAS
𝑟𝑝	0.220	−0.090	−0.151	0.443	0.132	−0.206	0.049	−0.005		−0.424	−0.040
𝑃	0.065	0.456	0.209	0.000	0.274	0.085	0.682	0.967		0.090	0.879
𝑛	72	72	72	72	72	72	72	72		18	18
LH
𝑟𝑝	−0.040	0.213	0.261	0.133	0.103	0.148	0.196	0.217	0.008		−0.024
𝑃	0.740	0.075	0.028	0.268	0.394	0.219	0.102	0.069	0.947		0.926
𝑛	72	72	72	72	72	72	72	72	72		18
PRL
𝑟𝑝	0.172	−0.120	−0.181	0.070	−0.070	−0.211	−0.022	0.020	0.416	−0.028
𝑃	0.152	0.320	0.130	0.563	0.563	0.078	0.856	0.868	0.000	0.819
𝑛	72	72	72	72	72	72	72	72	72	72

^∗𝑃=0.034 (𝑟-to-𝑧 method, validated as 𝑃=0.002, in the MRA model, as specified in Section 2.3).