Controlled Cohort Study of Serum Gonadal and Adrenocortical Steroid Levels in Males Prior to Onset of Rheumatoid Arthritis (pre-RA): A Comparison to pre-RA Females and Sex Differences among the Study Groups

Table 4

Age- and sex-adjusted correlations for total pre-RA (top) and CN (bottom) log values (imputed in females).

	E2/test	OH-PREG	OH-P4	DHEA	ADIONE	Test	E2	Cortisol	DHEAS	LH	PRL
E2/test
𝑟𝑝		0.177	0.402	0.065	𝟎.𝟐𝟒𝟐^∗	−0.536	0.757	0.160	0.084	−0.29	−0.142
𝑃		0.214	0.003	0.651	0.087	0.000	0.000	0.262	0.556	0.039	0.32
𝑛		54	54	54	54	54	54	54	54	54	54
OH-PREG
𝑟𝑝	−0.059		0.612	0.716	0.545	0.135	0.218	0.321	0.280	−0.047	0.051
𝑃	0.389		0.000	0.000	0.000	0.338	0.121	0.020	0.045	0.739	0.717
𝑛	216		54	54	54	54	54	54	54	54	54
OH-P4
𝑟𝑝	0.188	0.681		0.333	0.452	−0.134	0.350	−0.055	0.064	−0.294	0.094
𝑃	0.006	0.000		0.016	0.001	0.343	0.011	0.697	0.654	0.034	0.507
𝑛	216	216		54	54	54	54	54	54	54	54
DHEA
𝑟𝑝	−0.191	0.608	0.373		0.664	0.319	0.138	0.416	0.492	−0.017	−0.157
𝑃	0.005	0.000	0.000		0.000	0.021	0.328	0.002	0.000	0.902	0.267
𝑛	216	216	216		54	54	54	54	54	54	54
ADIONE
𝑟𝑝	−0.090	0.460	0.396	0.724		0.213	0.418	0.292	0.338	0.062	−0.119
𝑃	0.191	0.000	0.000	0.000		0.129	0.002	0.036	0.014	0.662	0.399
𝑛	216	216	216	216		54	54	54	54	54	54
Test
𝑟𝑝	−0.605	0.315	0.116	0.321	0.293		−0.104	0.216	−0.110	0.188	−0.042
𝑃	0.000	0.000	0.091	0.000	0.000		0.464	0.124	0.439	0.181	0.769
𝑛	216	216	216	216	216		54	54	54	54	54
E2
𝑟𝑝	0.525	0.177	0.354	0.091	0.208	0.098		0.139	0.023	−0.344	−0.061
𝑃	0.000	0.009	0.000	0.187	0.002	0.152		0.324	0.870	0.013	0.670
𝑛	216	216	216	216	216	216		53	54	54	54
Cortisol
𝑟𝑝	−0.094	0.308	0.027	0.300	0.236	0.054	−0.118		0.055	−0.057	−0.159
𝑃	0.172	0.000	0.698	0.000	0.001	0.433	0.086		0.696	0.687	0.262
𝑛	216	216	216	216	216	216	216		54	54	54
DHEAS
𝑟𝑝	0.037	0.163	0.097	0.438	0.317	−0.047	0.047	−0.044		0.121	−0.053
𝑃	0.590	0.017	0.158	0.000	0.000	0.492	0.493	0.520		0.392	0.708
𝑛	216	216	216	216	216	216	216	216		54	54
LH
𝑟𝑝	−0.092	−0.004	−0.186	0.060	0.043	0.094	−0.055	0.118	−0.107		−0.063
𝑃	0.180	0.952	0.006	0.386	0.532	0.170	0.423	0.084	0.117		0.656
𝑛	216	216	216	216	216	216	216	216	216		54
PRL
𝑟𝑝	0.082	−0.078	0.007	−0.061	−0.063	−0.211	0.002	0.034	0.072	0.071
𝑃	0.232	0.254	0.923	0.378	0.361	0.002	0.980	0.617	0.294	0.302
𝑛	216	216	216	216	216	216	216	216	216	216

^∗𝑃=0.034 (𝑟-to-𝑧 method, validated as 𝑃=0.015, in the MRA model, as specified in Section 2.3).