Review Article

The Role of Citrullinated Protein Antibodies in Predicting Erosive Disease in Rheumatoid Arthritis: A Systematic Literature Review and Meta-Analysis

Table 1

Studies included in the systematic review.

AuthorYearStudy typeCohort sizeStudy duration in yearsAnti-CCPOther ACPAErosionsSvdHLarsen

Fisher et al. [23]2011Prospective408550%27% (anti-CEP1)8
Mansour et al. [24]2010Prospective123242% (anti-MCV)77%
Hetland et al. [25] 2010Double-blind randomized110558%13
Plant and Thomson [26]2010Prospective269556%48%10
Kim et al. [27] 2010Longitudinal216282%75%
Sanmartí et al. [28]2009Randomized controlled322274%83% (anti-CFFCP)70%7
Rojas-Villarraga et al. [20]2009Prospective157379%6
van der Linden et al. [29]2009Longitudinal687567%92% (anti-MCV)48
Syversen et al. [21] 2010Longitudinal1251063%64% (anti-MCV)54%50
Reneses et al. [30]2009Prospective134154%36%
Innala et al. [10]2008Randomized controlled210286%96% (anti-MCV)66%12
Courvoisier et al. [31]2008Prospective1121058%70%46
Mathsson et al. [22]2008Randomized controlled273258%71% (anti-MCV)71.00%18
Bukhari et al. [18]2007Controlled cross-sectional427570%79%29
Karlson et al. [32] 2008Prospective689567%59%
Machold et al. [17] 2007Controlled cross-sectional55363%65%75
Mewar et al. [33]2006Prospective872377%77%49
Kaltenhäuser et al. [19] 2007Prospective126669%65%29
Meyer and Nicaise-Roland [34]2006Prospective172364%57%5
Boire et al. [35]2005Prospective165253%48% (anti-MCV)64.00%34
Bongi et al. [36]2004Controlled cross-sectional89188%49%
Lindqvist et al. [37] 2005Prospective1861080%83%37
Jansen et al. [38]2003Prospective289265%34%19
Orbach et al. [39] 2002Prospective101159%63%
Vencovský et al. [40] 2003Prospective104247%64%18

Erosions: the percentage of patients that showed progressive erosive change.
SvdH: the highest Sharp score recorded, with asterisk the change in Sharp score.
Larsen: the highest Larsen score recorded.