Gynaecological Screening for Cervical and Vulvar Malignancies in a Cohort of Systemic Sclerosis Patients: Our Experience and Review of the Literature

Table 2

Cervical or vulvar cancers in SSc patients: review of the literature.

First author, year [ref.]	Country	Type of study	patient-years^1  (pts/follow-up)	Cervical cancer	Vulvar cancer
Duncan, 1979 [9]	Mayo Clinic, USA	Cohort study	(2,141/n.d.^2)	10	1
Lee, 1983 [10]	Canada	Cohort study	(95/7.3 ± 6.6)	2	0
Kyndt, 1997 [11]	France	Cohort study	(123/median 4)	1	0
Hill, 2003 [12]	South Australia	Registry-based	(441/6.1 ± 2.8)	5	0
Chatterjee, 2005 [13]	Detroit area, USA	Registry-based	4,908	3 (2 in situ)	0
Derk, 2006 [14]	Pennsylvania, USA	Cohort study	3,775	4	1
Olesen, 2010 [15]	Denmark	Registry-based	16,003	9	0
Airo’, 2011 [16]	Italy	Cohort study	4,041	1	1
Belloli, 2011 [17]	Italy	Cohort study	(112/n.d.^3)	3^4	0
Szekanecz, 2012 [18]	Hungary	Cohort study	(218/n.d.)	1	0
Moinzadeh, 2014 [19]^5	United Kingdom	Cohort study	(2,177/median 12.8)	17 “gynaecological” cases
Shah, 2015 [20]^6	John Hopkins H, USA	Cross-sectional	(1,044/1990–2012)	3	1
Present series	Italy	Cohort study	560	2 (1 in situ)	2 (1 in situ)

() When the number of patient-years is not reported, number of patients (pts) and number of years of follow-up are indicated in parenthesis. () Authors reviewed histories of SSc patients seen between 1959 and 1975. () Authors indicated that the follow-up was approximately from 2004 to November 2009. () Uterine cancers. n.d.: not done. () This study considered the database of SSc patients followed at the Centre for Rheumatology and Connective Tissue Diseases of the Royal Free Hospital, London. The “gynaecological” cases of cancer were not better defined, and were not classified either before or after SSc onset. () This study evaluated the database of SSc patients observed at the John Hopkins Scleroderma Centre, Baltimore, in the period from 1990 to 2012. Other 5 cases of cancer of the endometrium were cited.
All SSc series studied included male patients, except our cohort.
In our study, 2 cases of cervical cancer and 2 cases of vulvar cancers were found, as reported; the further case who presented an endocervical polyp with immature squamous metaplasia is not indicated.