Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage

Figure 5

AMPK expression. Relative gene expression in (a) articular cartilages of healthy () and OA patients () and in (b) PBMCs of the same OA patients () versus 16 healthy subjects, as determined by real-time PCR analyses with reference to β-actin. (c) pAMPK protein concentrations in PBMCs of the same OA patients () versus 16 healthy subjects as determined by ELISA. Asterisks () indicate significant differences from controls (Mann–Whitney U test).

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