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International Journal of Rheumatology
Volume 2017 (2017), Article ID 7687053, 8 pages
https://doi.org/10.1155/2017/7687053
Clinical Study

Effect of Curcuma xanthorrhiza Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D3 towards Disease Activity (SLEDAI), IL-6, and TGF-β1 Serum

1Rheumatology and Immunology Division, Department of Internal Medicine, Faculty of Medicine, Brawijaya University and Saiful Anwar General Hospital, Malang, Indonesia
2Department of Internal Medicine, Faculty of Medicine, Brawijaya University and Saiful Anwar Hospital, Malang, Indonesia
3Pharmacology Department, Faculty of Medicine, Brawijaya University, Malang, Indonesia
4Clinical Pathology Department, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia

Correspondence should be addressed to Handono Kalim; moc.liamg@333milakh

Received 8 May 2017; Revised 13 September 2017; Accepted 25 September 2017; Published 28 December 2017

Academic Editor: Charles J. Malemud

Copyright © 2017 C. Singgih Wahono et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Curcumin contained in Curcuma xanthorrhiza is an immunomodulator that has similar biological effect as vitamin D. Combination of curcumin and vitamin D3 is expected to work synergistically. Objective. To determine the effect of Curcuma xanthorrhiza supplementation on vitamin D3 administration to SLEDAI, IL-6, and TGF-β1 serum in SLE patients with hypovitamin D. Methods. This was a double-blind RCT conducted in Saiful Anwar Hospital, Malang, in January 2016–March 2017. Subjects were SLE active (SLEDAI > 3) with levels of 25(OH)D3 ≤ 30 ng/ml and divided into two groups: those receiving cholecalciferol 3 × 400 IU and placebo 3 × 1 tablets (group I) and those receiving 3 × 400 IU cholecalciferol and Curcuma xanthorrhiza 3 × 20 mg for 3 months (group II). SLEDAI, levels of vitamin D, IL-6, and TGF-β1 in serum were evaluated before and after the treatment. Results. There were no significant differences in SLEDAI reduction, decreased serum levels of IL-6, and increased levels of TGF-β1 serum among groups after the treatment. Decreased levels of serum IL-6 have a positive correlation with SLEDAI reduction. Conclusion. Curcuma xanthorrhiza supplementation on vitamin D3 had no effects on SLEDAI and serum levels of IL-6 and TGF-β1. This clinical trial is registered with NCT03155477.