Table 3: Study of 73 AS patients between 35 and 50 years without cardiovascular events, diabetes mellitus, or chronic kidney disease. Sensitivity, specificity, percentage of correctly classified patients, and area under the ROC curve of three different models based on the TC-SCORE algorithm, the relative risk (RR) chart score, and a value of CRP higher than 3 mg/L at time of disease diagnosis along with the performance of carotid (US) to establish the presence of high/very high cardiovascular risk.

SensitivitySpecificityCorrectly classifiedROC [95% CI]

Model 1
TC-SCORE ≥ 5% OR
TC-SCORE ≥ 1% <5% plus carotid Carotid US (presence of plaques)
40%88.7%75.3%0.64 [0.53–0.76]

Model 2
RR > 1 and CRP > 3 mg/L at time of disease diagnosis plus carotid US (presence of plaques)
60.0%77.4%72.6%0.69 [0.56–0.81]

Model 3
RR > 1 plus carotid US (presence of plaques)
75.0%56.6%61.6%0.66 [0.53–0.78]

TC-SCORE: total cholesterol systematic coronary risk evaluation, US: ultrasound, RR: relative risk, and CRP: C-reactive protein. The gold standard used to define high/very high cardiovascular risk was the presence of TC-SCORE ≥ 5% or carotid plaques.