(a)
(b)
(c)
(d)
Figure 3: The genes that shows the most significant changes in DNA methylation and gene expression. (a) Flowchart of identification of genes showing coordinately changed DNA methylation and gene expression. (b) Venn diagram of differential DNA methylation and differential gene expression analysis. (c) The top-rank relevant differentially methylated sites with different gene expression in SSc compared with controls. The y-axis represents fold change of gene expression between SSc and normal control. The y-axis represents of DNA methylation between SSc and normal control. (d) Correlation plots of DNA methylation versus gene expression in SScs and normal for the most significant changes in DNA methylation and gene expression.