Clinical Outcomes of Myocarditis after Moderate-Dose Steroid Therapy in Systemic Sclerosis: A Pilot Study
Table 1
Overall baseline clinical characteristics.
Variable
Female (%)
13 (65)
Age on enrollment (years);
BMI (kg/m2);
Duration of disease (years);
Diffuse cutaneous SSc (%)
15 (75)
NYHA functional class II
20 (100)
Serology
Anti-topoisomerase antibody positive (%)
19 (95)
Anti-centromere antibody positive (%)
1 (5)
Clinical characteristic
Raynaud’s phenomenon (%)
12 (60)
Digital ulcer (%)
3 (15)
Edematous skin (%)
11 (55)
Tendon friction rub (%)
12 (60)
Hand deformity (%)
14 (70)
Esophageal involvement (%)
4 (20)
Stomach involvement (%)
3 (15)
Modified Rodnan skin score (points);
Pulmonary involvement (%)
12 (60)
Pulmonary arterial hypertension (%)
3 (15)
Renal crisis (%)
0
Laboratory result
Anemia (%)
9 (45)
Hemoglobin (g/dL);
Erythrocyte sedimentation rate > 25 mm/h (%)
17 (85)
C-reactive protein >5 mg/dl (%)
13 (65)
CK-MB >25 U/L (%)
12 (60)
Hs-cTnT >0.014 ng/ml (%)
16 (80)
Hs-cTnT;
High NT-proBNP (%)
4 (20)
NT-proBNP;
Estimated GFR (ml/min/1.73m2);
Forced vital capacity (%predicted);
Radiographic result
Cardiomegaly by chest radiography (%)
5 (25)
Ground glass opacification by HRCT chest (%)
12 (60)
Echocardiography result
LV ejection fraction (%)
Impaired LV systolic function (LV ejection fraction <50%) (%)
2 (10)
Tricuspid velocity jet (m/sec)
Right ventricular systolic pressure (mmHg);
E’ velocity (cm/sec);
Pericardial effusion (%)
8 (40)
CMR finding
LV ejection fraction (%);
LV stroke volume (ml);
LV cardiac output (L/min);
RV ejection fraction (%);
RV stroke volume (ml);
RV cardiac output (L/min);
Pericardial effusion (%)
16 (80)
BMI denotes body mass index; CK-MB: creatine kinase-muscle/brain; CMR: cardiovascular magnetic resonance; GFR: glomerular filtration rate; hs-cTnT: high sensitivity of cardiac Troponin-T; HRCT: high-resolution computed tomography; LV: left ventricular; NT-proBNP: NT-prohormone-brain natriuretic peptide; NYHA: New York Heart Association; RV: right ventricular; SD: standard deviation; SSc: systemic sclerosis.
