Research Article
A Comparative Study to Assess the Efficacy of Two Different Estradiol Formulations during In Vitro Fertilization
Table 6
Measures of secondary outcome of the two treatments.
| | Enrolled number of patients | Pregnancy rate (PR) (%) | Clinical pregnancy rate (CPR) (%) | Clinical abortion (CAB) (%) | Ectopic (EC) (%) | Live birth rate (LBR) (%) |
| | Thaw self | | Estradiol valerate | 734 | 457 (62.26%) | 416/734 (56.68%) | 91/416 (21.88%) | 3/416 (0.72%) | 322/734 (43.87%) | | Estradiol hemihydrate | 453 | 288 (63.58%) | 265/453 (58.50%) | 49/265 (18.49%) | 1/265 (0.38%) | 215/453 (47.46%) | | value | | 0.648 | 0.535 | 0.286 | — | 0.227 | | Fresh OD/ED | | Estradiol valerate | 415 | 308 (74.21%) | 280/415 (67.47%) | 50/280 (17.86%) | 0 | 230/415 (55.42%) | | Estradiol hemihydrate | 202 | 150 (74.25%) | 135/202 (66.83%) | 23/135 (17.04%) | 0 | 112/202 (55.45%) | | value | | 0.9912 | 0.874 | 0.837 | — | 0.382 | | Thaw OD/ED | | Estradiol valerate | 407 | 252 (61.92%) | 216/407 (53.07%) | 58/216 (26.85%) | 0 | 158/407 (38.82%) | | Estradiol hemihydrate | 265 | 167 (63.02%) | 148/265 (55.85%) | 34/148 (22.97%) | 0 | 114/265 (43.02%) | | value | | 0.773 | 0.48 | 0.403 | — | 0.631 | | Total | | Estradiol valerate | 1556 | 1017 (65.36%) | 912/1556 (58.61%) | 199/912 (21.82%) | 3/912 (0.33% | 710/1556 (45.63%) | | Estradiol hemihydrate | 920 | 605 (65.76%) | 548/920 (59.57%) | 106/548 (19.34%) | 1/548 (0.18%) | 441/920 (47.93%) | | value | | 0.84 | 0.625 | 0.259 | — | 0.532 |
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PR: pregnancy rate; CPR: clinical pregnancy rate; CAB: clinical abortion; EC: ectopic pregnancy; LBR: live birth rate; OD/ED: donor oocyte/donor embryo; NPR, NCR, NEC, and NLBR: number of instances of pregnancy, clinical pregnancy, ectopic pregnancy, and live birth rate, respectively.
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