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International Journal of Spectroscopy
Volume 2011 (2011), Article ID 640121, 7 pages
Research Article

Molecular Self-Assembling of 𝑁 -Methylacetamide in Solvents

Department of Chemistry, School of Science, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0373, Japan

Received 28 April 2011; Accepted 27 June 2011

Academic Editor: Sergio Armenta Estrela

Copyright © 2011 Hideyuki Minami and Makio Iwahashi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The self-association of 𝑁 -methylacetamide (NMA), which is one of the most simple compound having a peptide bond, in various solvents such as carbon tetrachloride (CCl4), chloroform, dichloromethane, and acetonitrile was studied through the near-infrared (NIR) spectroscopic observation at various temperatures and concentrations. An analysis assuming a successive association processes for the NMA molecules was applied to the sharp 1470-nm band (the first-overtone band of NH stretching vibration mode attributed to free NH group of NMA monomer and partly to the free, terminal NH group of NMA aggregate); the mean association number for NMA in CCl4 increases with increasing concentration and decreases with increasing temperature. Comparisons of the association number of NMA in various solvents indicate that the degree of association is in the following order: C C l 4 chloroform dichloromethane > acetonitrile. Interestingly, the association number of NMA in CCl4 is thought to be larger than that in its pure liquid.