Table of Contents Author Guidelines Submit a Manuscript
International Journal of Surgical Oncology
Volume 2011, Article ID 184891, 5 pages
Case Report

Intraosseous Synovial Sarcoma of the Proximal Tibia

1Department of Orthopaedics, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
2Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA

Received 15 November 2010; Accepted 28 February 2011

Academic Editor: Masaki Mori

Copyright © 2011 Sarah E. Beck et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Synovial Sarcoma is a malignant mesenchymal tumor that comprises 5–10% of all soft tissue sarcomas. The mean age of onset is thirty years old. Intraosseous presentation is very rare and has only been documented a few times. We report herein a case of a 53-year-old man with synovial sarcoma arising in the left proximal tibia. The patient underwent a wide surgical resection and reconstruction, followed by adjuvant chemotherapy. Three years later, the patient developed a local recurrence that resulted in an above-the-knee amputation. Eight months later, the patient has completed chemotherapy and is without signs of recurrence. The current recommended treatment for synovial sarcoma is wide surgical resection followed by chemotherapy as well as long-term followup. Despite improved surgical techniques, long-term survival rates remain low.

1. Introduction

Synovial sarcoma usually arises in the soft tissues of the extremities and rarely presents as a primary bone tumor. The first reported case of an intraosseous synovial sarcoma occurred in the proximal tibia [1]. Since then, only two cases have been completely documented with histological and molecular genetic confirmation [2, 3]. Five additional incompletely documented cases have been reported [48].

Synovial sarcoma is a malignant soft tissue tumor that comprises 5–10% of all soft tissue sarcomas [3]. It most often affects adolescents and young adults and has a mean age of onset of 30 years [9], with less than 10% of patients being over the age of 60 [10].

It usually arises in the lower extremities [4]. The large majority of tumors appear near large joints, but it has also been reported to arise in a variety of other locations such as in the head and neck [11], chest [12], and abdomen [13]. While 20% show erosion or invasion of adjacent bone [14], primary synovial sarcoma of bone is extremely rare [3]. We report a case of primary intraosseous synovial sarcoma arising in the proximal tibia.

2. Case Report

A 53-year-old man presented with a 3-month history of left knee pain. He had difficulty weight bearing and complained of swelling of the calf as well as a lack of sensation in the toes. X-rays showed a large, 5 cm round lucency involving the lateral proximal portion of the tibia (Figure 1(a)). The lateral view showed stippled mineralization extending into the soft tissues posteriorly (Figure 1(b)). MRI showed a large mass in the tibial plateau of the left proximal tibia with a soft tissue extension postero-laterally.

Figure 1: (a) A/p radiograph of the left knee shows a round lucency at the lateral tibial plateau with well-defined proximal margins and a less well-defined distal margin.(b) Lateral radiograph shows a stippled mineralization (arrow) projecting into the soft tissues posteriorly, measuring approximately 2.5 cm in maximal diameter.

Chest X-ray was negative for metastatic disease. A CT scan of the chest, pelvis, and abdomen along with a bone scan were negative except for an increased uptake in the proximal tibia. A core needle biopsy was performed revealing a high-grade sarcoma. A proximal tibial resection with negative margins was performed. Grossly, the tumor was tan-yellow, arising in the proximal tibia and extending into the adjacent soft tissue. The intraosseous component measured  cm and the extraosseous soft tissue component measured  cm (Figure 2). Histologically, the tumor showed the characteristic features of a biphasic synovial sarcoma, containing obvious glandular differentiation admixed with a malignant spindle cell component (Figures 3(a) and 3(b)). Immunohistochemical studies showed that the neoplastic cells were positive for keratin, cytokeratin 7, and epithelial membrane antigen (EMA). Fluorescence in situ hybridization (FISH) analysis was performed on interphase nuclei isolated from f paraffin-embedded 50 μm tissue sections, for the detection of possible t(X;18)(p11;q11). An SS18 rearrangement was observed in 49/50 nuclei examined, confirming the diagnosis of synovial sarcoma (Figure 4). An endoprosthetic reconstruction was performed using a cemented prosthesis (Figures 5(a) and 5(b)). The patient was treated with adjuvant chemotherapy including dacarbazine, doxorubicin, ifosfamide, and mesna.

Figure 2: Grossly the tumor is eccentrically located in the proximal tibia. It has a tan-grey fleshy cut surface, which breaks through the cortex and extends into adjacent soft tissue (right).
Figure 3: (a) Photomicrograph of intraosseous synovial sarcoma. The tumor is present in the medullary cavity of the bone (left), infiltrates the cortex, and expands the haversian systems. (Stain, hematoxylin, and eosin; original magnification, ×40). (b) Photomicrograph of intraosseous synovial sarcoma. The tumor shows a typical biphasic pattern with glandular differentiation admixed with spindle-shaped cells. (Stain, hematoxylin, and eosin; original magnification, ×400).
Figure 4: Interphase nuclei showing an abnormal hybridization pattern using the Vysis LSI SS18 Dual Color, Break Apart Rearrangement Probe at 18q11.2 (Abbott Molecular). SS18 gene rearrangement appeared as a separation of the red-orange and green signals from the normal fusion signal (yellow).
Figure 5: Postoperative anterior posterior, (a) and lateral (b) radiographs of the left knee demonstrate the endoprosthetic reconstruction of the proximal tibia and knee joint.

Three years later, the patient presented again with left knee pain. A PET/CT scan revealed multiple soft tissue nodules above and below the knee (Figures 6(a) and 6(b)). A CT scan of the chest was negative. A fine needle aspiration revealed recurrent synovial sarcoma. The patient underwent an above-the-knee amputation with prosthetic reconstruction.

Figure 6: (a) A preoperative CT scan reveals multiple soft tissue nodules (arrow) above and below the knee including areas medial, lateral, anterior, posterior and in the suprapatellar recess. (b) A preoperative PET scan shows intense FDG uptake in the multiple soft tissue nodules above and below the knee consistent with recurrent disease.

The resection specimen showed soft tissue nodules above and below the knee with a large soft tissue component as well as involvement of the distal femur. The tumor measured  cm in its largest dimension. Again, the tumor was noted to be biphasic synovial sarcoma. The patient was restarted on adjuvant chemotherapy including mesna, adriamycin, ifosfamide, and dacarbazine. Eight months have passed since the amputation. He continues adjuvant chemotherapy and has no other sites of disease.

3. Discussion

Synovial sarcoma was originally named in 1936 by Knox as it was believed to be of synovial cell origin [3]. This term is misleading as many cases of synovial sarcoma have been found to originate elsewhere where no synovial tissue is present, and at this time, the tumor is regarded as a neoplasm of “uncertain histogenesis” [15]. Many cases occur outside of the synovium and less than 5% of synovial sarcomas actually originate in a joint or bursa [14]. While 20% of synovial sarcomas show invasion of local bone, it is extremely rare for it to present as a primary bone tumor [14].

We believe that our case represents a primary bone tumor because the osseous extent of the tumor is greater than the soft tissue component. In addition, our imaging studies suggest that the epicenter of the tumor began in bone and grew secondarily into soft tissues.

Radiographically, synovial sarcoma presents with MR findings of heterogeneous intermediate signal intensity on T1W1, heterogeneous high signal intensity on fat-suppressed T2W1, and heterogeneous contrast enhancement [3]. Histologically, synovial sarcoma is classified as biphasic, monophasic, or poorly differentiated [15], with the biphasic being the most common. Synovial sarcoma is locally aggressive, and distant metastases are common [9]. Additionally the diagnosis of synovial sarcoma can be confirmed genetically with the detection of t(X;18)(p11.2;q11.2). This translocation involves the SS18 (a.k.a.SYT) gene on chromosome 18 and either the SSX1, SSX2, or rarely the SSX4 gene on the X chromosome [15]. This translocation occurs in more than 90% of all synovial sarcomas [10].

Synovial sarcoma of bone was first reported in 1997 [1]. Since then confirmed cases of primary synovial sarcoma of bone have been found in the sacrum [6], distal tibia [7], mandible [8], elbow [2, 4], distal tibia [3], and sternum [5]. Due to its aggressive nature, recommended treatment is a combination of wide surgical resection to achieve clear margins, followed by chemotherapy and/or irradiation. Long-term follow-up is necessary due to this tumor’s high rate of recurrence and metastasis [16].

Development of distant metastasis and decreased disease-specific survival has been correlated to a large tumor size (greater than 5 cm) and invasion of bone, nerve, or vascular structures [16, 17]. In 1950, a study of 60 patients treated only with simple excision showed a 63% local recurrence rate [18]. As a result of this study, simple excision as the solitary form of treatment is no longer being practiced.

Studies have shown clear indications for the use of irradiation therapy for local control of synovial sarcoma. In 2000, Lewis et al. showed a local recurrence of only 10% in their series of 112 patients with primary localized tumors of the extremity [17]. Approximately half of the patients in this study also underwent adjuvant irradiation. The authors thus attributed this better local recurrence rate, in comparison to the 1950 study, to improved surgical techniques as well as to the use of adjuvant radiation [17].

While the rate of local recurrence has diminished, the rate of distant metastasis is still a challenge for clinicians. Lewis et al. found a 40% chance of metastasis within five years, despite wide surgical resection with negative margins [17]. Five-year survival rate has been reported to be as low as 25–50%, while ten-year survival rate is only 10–15% [8]. While the use of chemotherapy for systemic control has been previously questioned, a recent study has shown that chemotherapy treatment is significantly associated with an increased 4-year disease-specific survival (DSS) [16]. The 4-year DSS was 88% in the ifosfamide- treated patients and 67% in the patients that did not receive chemotherapy [16].

We chose chemotherapy treatment over radiation following surgical resection in order to decrease the chance of distant metastasis. The primary tumor, being larger than 5 cm, had an increased chance of distant metastasis [17]. There was also a significant soft tissue component. The recurrent tumor displayed multiple soft tissue nodules that indicated it was at least a regional, if not a systemic problem that would also increase the chance for metastasis.

Overall, these recent studies are showing a positive progression of treatment methods. The lower rates of local recurrence are promising, but the low five-year survival rates and the high chance of distant metastasis still show the need for the development of adequate systemic therapy. Due to the aggressive nature of this disease and the high rate of metastasis, long-term follow-up is essential.


The authors thank Charles Carrier, B.A., and Paola Dal Cin, Ph.D, for their contribution to this paper. Institution has approved the reporting of this case report, all investigations were conducted in conformity with ethical principles of research, and informed consent for participation in the study was obtained.

Work performed at the Department of Orthopaedics, Massachusetts General Hospital and Harvard Medical School, Boston.

Conflict of Interests

Each author certifies that he or she has no commercial associations (e.g consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interests in connection with the submitted paper.


  1. I. J. Cohen, J. Issakov, S. Avigad et al., “Synovial sarcoma of bone delineated by spectral karyotyping,” Lancet, vol. 350, no. 9092, pp. 1679–1680, 1997. View at Publisher · View at Google Scholar
  2. H. Hiraga, T. Nojima, K. Isu, K. Yamashiro, S. Yamawaki, and K. Nagashima, “Histological and molecular evidence of synovial sarcoma of bone: a case report,” Journal of Bone and Joint Surgery A, vol. 81, no. 4, pp. 558–563, 1999. View at Google Scholar
  3. S. C. Jung, J. A. Choi, J. H. Chung, J. H. Oh, J. W. Lee, and H. S. Kang, “Synovial sarcoma of primary bone origin: a rare case in a rare site with atypical features,” Skeletal Radiology, vol. 36, no. 1, pp. 67–71, 2007. View at Publisher · View at Google Scholar · View at PubMed
  4. P. O'Donnell, T. C. Diss, J. Whelan, and A. M. Flanagan, “Synovial sarcoma with radiological appearances of primitive neuroectodermal tumour/Ewing sarcoma: differentiation by molecular genetic studies,” Skeletal Radiology, vol. 35, no. 4, pp. 233–239, 2006. View at Publisher · View at Google Scholar · View at PubMed
  5. M. Nakajo, K. Ohkubo, T. Nandate et al., “Primary synovial sarcoma of the sternum: computed tomography and magnetic resonance imaging findings,” Radiation Medicine, vol. 23, no. 3, pp. 208–212, 2005. View at Google Scholar
  6. C. Sar and L. Eralp, “Surgical treatment of primary tumors of the sacrum,” Archives of Orthopaedic and Trauma Surgery, vol. 122, no. 3, pp. 148–155, 2002. View at Publisher · View at Google Scholar · View at PubMed
  7. S. P. Scully, H. T. Temple, and J. M. Harrelson, “Synovial sarcoma of the foot and ankle,” Clinical Orthopaedics and Related Research, no. 364, pp. 220–226, 1999. View at Google Scholar
  8. W. M. Tilakaratne, “Synovial sarcoma of the mandible,” Journal of Oral Pathology and Medicine, vol. 35, no. 1, pp. 61–63, 2006. View at Publisher · View at Google Scholar · View at PubMed
  9. B. W. Scheithauer, A. I. Silva, K. Kattner, J. Seibly, A. M. Oliveira, and K. Kovacs, “Synovial sarcoma of the sellar region,” Neuro-Oncology, vol. 9, no. 4, pp. 454–459, 2007. View at Publisher · View at Google Scholar · View at PubMed
  10. R. Jeganathan, R. Davis, L. Wilson, J. McGuigan, and P. Sidhu, “Primary mediastinal synovial sarcoma,” Ulster Medical Journal, vol. 76, no. 2, pp. 109–111, 2007. View at Google Scholar
  11. G. A. Barkan and A. K. El-Naggar, “Primary synovial sarcoma of the parotid gland,” Annals of Diagnostic Pathology, vol. 8, no. 4, pp. 233–236, 2004. View at Publisher · View at Google Scholar
  12. A. K. Anand, A. Khanna, S. K. Sinha, U. Mukherjee, J. S. Walia, and A. N. Singh, “Pericardial synovial sarcoma,” Clinical Oncology, vol. 15, no. 4, pp. 186–188, 2003. View at Publisher · View at Google Scholar
  13. C. Fisher, A. L. Folpe, H. Hashimoto, and S. W. Weiss, “Intra-abdominal synovial sarcoma: a clinicopathological study,” Histopathology, vol. 45, no. 3, pp. 245–253, 2004. View at Publisher · View at Google Scholar · View at PubMed
  14. M. Vliet, M. Kliffen, G. P. Krestin, and C. F. Dijke, “Soft tissue sarcomas at a glance: clinical, histological, and MR imaging features of malignant extremity soft tissue tumors,” European Radiology, vol. 19, no. 6, pp. 1499–1511, 2009. View at Publisher · View at Google Scholar · View at PubMed
  15. M. Haldar, R. L. Randall, and M. R. Capecchi, “Synovial sarcoma: from genetics to genetic-based animal modeling,” Clinical Orthopaedics and Related Research, vol. 466, no. 9, pp. 2156–2167, 2008. View at Publisher · View at Google Scholar · View at PubMed
  16. F. C. Eilber, M. F. Brennan, F. R. Eilber et al., “Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma,” Annals of Surgery, vol. 246, no. 1, pp. 105–113, 2007. View at Publisher · View at Google Scholar · View at PubMed
  17. J. J. Lewis, C. R. Antonescu, D. H. Y. Leung et al., “Synovial sarcoma: a multivariate analysis of prognostic factors in 112 patients with primary localized tumors of the extremity,” Journal of Clinical Oncology, vol. 18, no. 10, pp. 2087–2094, 2000. View at Google Scholar
  18. G. T. Pack and I. M. Ariel, “Synovial sarcoma (malignant synovioma). A report of 60 cases,” Surgery, vol. 28, no. 6, pp. 1047–1084, 1950. View at Google Scholar