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International Journal of Surgical Oncology
Volume 2011, Article ID 748745, 8 pages
http://dx.doi.org/10.1155/2011/748745
Review Article

Lymph Node Dissection in Curative Gastrectomy for Advanced Gastric Cancer

Department of Surgery, Kansai Rosai Hospital, 1-69 3-Chome, Inabasou, Amagasaki, Hyogo 660-8511, Japan

Received 15 January 2011; Accepted 29 March 2011

Academic Editor: Michael Hünerbein

Copyright © 2011 Shigeyuki Tamura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gastric cancer is one of the most common causes of cancer-related death worldwide. Surgical resection with lymph node dissection is the only potentially curative therapy for gastric cancer. However, the appropriate extent of lymph node dissection accompanied by gastrectomy for cancer remains controversial. In East Asian countries, especially in Japan and Korea, D2 lymph node dissection has been regularly performed as a standard procedure. In Western countries, surgeons perform gastrectomy with D1 dissection only because D2 is associated with high mortality and morbidity compared to those associated with D1 alone but does not improve the 5-year survival rate. However, more recent studies have demonstrated that western surgeons can be trained to perform D2 lymphadenectomies on western patients with a lower morbidity and mortality. When extensive D2 lymph node dissection is preformed safely, there may be some benefit to D2 dissection even in western countries. In this paper, we present an update on the current literature regarding the extent of lymphadenectomy for advanced gastric cancer.