Lymph Node Dissection in Curative Gastrectomy for Advanced Gastric Cancer

Table 4

Randomized controlled trials comparing D1 with D2/D3.

Study	Country	Comparison	Postoperative; morbidity	Postoperative; mortality	5-year survival
Dutch trial; (1989–1993)	Netherlands	D1 (𝑛=380); D2 (𝑛=331)	25%; 43%; (𝑃<.001)	4%; 10%; (𝑃=.004)	45%; 47%; HR 1.00; (95% CI, 0.82–1.22)
MRC trial; (1987–1994)	UK	D1 (𝑛=200); D2 (𝑛=200)	28%; 46%; (𝑃<.001)	6.5%; 13%; (𝑃=.04)	35%; 33%; HR 1.10; (95% CI, 0.87–1.39)
Taiwanese trial; (1993–1999)	Taiwan	D1 (𝑛=110); D3 (𝑛=111)	7.3%; 17.1%; (𝑃=.012)	0%; 0%	53.6%; 59.5%; HR 0.49; (95% CI, 0.32–0.77)
IGCSG trial; (1999–2002)	Italy	D1 (𝑛=76); D2 (𝑛=86)	10.5%; 16.3%; (𝑃<.029)	0%; 1.3%; (N.S)	Under analysis