Lymph Node Dissection in Curative Gastrectomy for Advanced Gastric Cancer
Table 4
Randomized controlled trials comparing D1 with D2/D3.
Study
Country
Comparison
Postoperative morbidity
Postoperative mortality
5-year survival
Dutch trial (1989–1993)
Netherlands
D1 D2
25% 43%
4% 10%
45% 47% HR 1.00 (95% CI, 0.82–1.22)
MRC trial (1987–1994)
UK
D1 D2
28% 46%
6.5% 13%
35% 33% HR 1.10 (95% CI, 0.87–1.39)
Taiwanese trial (1993–1999)
Taiwan
D1 D3
7.3% 17.1%
0% 0%
53.6% 59.5% HR 0.49 (95% CI, 0.32–0.77)
IGCSG trial (1999–2002)
Italy
D1 D2
10.5% 16.3%
0% 1.3% (N.S)
Under analysis
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