Clinical Study
Metastatic Medulloblastoma in Childhood: Chang's Classification Revisited
Table 2
Univariate and multivariate analysis of early Complete Response (CR) to sandwich chemotherapy.
| | | Univariate analysis | Multivariate analysis | | CR (%) | HR | IC (95%) | value | HR | IC (95%) | value |
| | Chang’staging | | | | | | | | | M1 () | 11 (50%) | 1 | | 0.006 | 1 | | 0.002 | | M2 () | 3 (12%) | 7.3 | 1.7–31.8 | 9.8 | 2.0–46.9 | | M3 () | 13 (19%) | 4.4 | 1.6–12.3 | 6.7 | 2.1–21.6 |
| | Qualitative classification | | | | | | | | | Positive CSF () | 11 (50%) | 1 | | 0.005 | 1 | | 0.002 | | Nodular () | 8 (22%) | 3.5 | 1.1–11.0 | | 6.3 | 1.7–23.7 | | | Laminar () | 8 (14%) | 6.4 | 2.1–19.5 | | 8.1 | 2.4–27.2 | |
| | Quantitative classification | | | | | | | | | Positive CSF () | 11 (50%) | 1 | | 0.003 | 1 | | 0.001 | | Localized () | 7 (27%) | 2.7 | 0.8–9.0 | 4.2 | 1.1–15.8 | | Extensive () | 9 (13%) | 6.7 | 2.2–19.8 | 9.7 | 2.9–32.9 |
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