Atypical Ductal Hyperplasia at the Margin of Lumpectomy Performed for Early Stage Breast Cancer: Is there Enough Evidence to Formulate Guidelines?

Table 2

Atypical ductal hyperplasia (ADH) and ipsilateral breast tumor recurrence (IBTR).

Investigator	no. BCS specimens	no. lumpectomy + for ADH	IBTR ADH (+) no. (%)	IBTR in ADH (−) no. (%)	Median Followup (years)
Goldstein et al. [33]	94	54	3/54 (5.6) ′	0/36 (0)′′	6.5
Fowble et al. [34]	460	99^†	1/99 (1.0)	17/329 (5.2)	4.8
Greene et al. [35]	155*	87	0/87 (0%)**	1/68 (1.5)**	2.2

′ADH (+) at margin more recurrence than ADH (−) at margin 𝑃<0.01.
′′Represents lesions negative for both ADH and COL.
^†ADH involved somewhere in specimen, not specifically involving margin.
*Lumpectomy performed for ADH, no malignancy in original specimen.
**denotes malignancy development and not recurrence as initial lumpectomy was negative for malignancy.