Review Article
Investigational Paradigms in Downscoring and Upscoring DCIS: Surgical Management Review
| Author and reference | Parameter | Results |
| Ottesen et al. [15] | Size | 10-year LR rates of DCIS treated by BCS alone () | | <10 mm | LR 11% | | >10 mm | LR 48% |
| Cutuli et al. [29] | Size | 5-year LR rates of BCS versus BCS + RT groups () | | <10 mm | LR 30% | LR 11% | | >10 mm | LR 31% | LR 13% |
| Dunne et al. [18] | Margin | Optimum margin threshold for DCIS resection ( | Number of patients | Negative Margin Width | Percentage of patients with IBTR (5-year follow-up) | 914 | No cells on ink | 9.4 | 1,239 | 1 mm margin | 10.4 | 207 | 2 mm margin | 5.8 | 154 | ≥5 mm margin | 3.9 |
| Kerlikowske et al. [57] | Nuclear Grade | Invasive LR rates of DCIS treated by BCS alone () |
| MacDonald et al. [43] | | | | Low-grade lesions | 6% | | High-grade lesions | 31.5% |
| Silverstein et al. [1] | VNPI Score | LR rates and DFS in three groups of DCIS patients () | (1) Non-high-grade DCIS without comedo-type necrosis | | | 3.8% | 93% | (2) Non-high-grade DCIS with comedo-type necrosis | | | 11.1% | 84% | (3) High-grade DCIS with or without comedo-type necrosis | | | 26.5% | 61% |
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