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International Journal of Surgical Oncology
Volume 2012, Article ID 635404, 9 pages
Review Article

Radiotherapy after Conservative Surgery in Ductal Carcinoma In Situ of the Breast: A Review

1ATreP, Agenzia Provinciale per la Protonterapia, Via Perini 181, 38122 Trento, Italy
2S.C. di Radioterapia, Azienda Ospedaliero-Universitaria, Via della Pietà 19, 34129 Trieste, Italy

Received 22 December 2011; Accepted 6 March 2012

Academic Editor: Bruno Cutuli

Copyright © 2012 Maurizio Amichetti and Cristiana Vidali. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Several large prospective and retrospective studies have demonstrated excellent long-term outcomes after breast conservative treatment with radiation in invasive breast cancer. Breast-conserving surgery (BCS) followed by radiotherapy (RT) is an accepted management strategy for patients with DCIS. Adding radiation treatment after conservative surgery enables to reduce, without any significant risks, the rate of local recurrence (LR) by approximately 50% in retrospective and randomized clinical trials. As about 50% of LRs are invasive and have a negative psychological impact, minimizing recurrence is important. Local and local-regional recurrences after initial breast conservation treatment with radiation can be salvaged with high rates of survival and freedom from distant metastases.