Table of Contents Author Guidelines Submit a Manuscript
International Journal of Surgical Oncology
Volume 2012, Article ID 635404, 9 pages
http://dx.doi.org/10.1155/2012/635404
Review Article

Radiotherapy after Conservative Surgery in Ductal Carcinoma In Situ of the Breast: A Review

1ATreP, Agenzia Provinciale per la Protonterapia, Via Perini 181, 38122 Trento, Italy
2S.C. di Radioterapia, Azienda Ospedaliero-Universitaria, Via della Pietà 19, 34129 Trieste, Italy

Received 22 December 2011; Accepted 6 March 2012

Academic Editor: Bruno Cutuli

Copyright © 2012 Maurizio Amichetti and Cristiana Vidali. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. D. Leonard and S. M. Swain, “Ductal carcinoma in situ, complexities and challenges,” Journal of the National Cancer Institute, vol. 96, no. 12, pp. 906–920, 2004. View at Google Scholar · View at Scopus
  2. J. Boyages, G. Delaney, and R. Taylor, “Predictors of local recurrence after treatment of ductal carcinoma in situ: a meta-analysis,” Cancer, vol. 85, no. 3, pp. 616–628, 1999. View at Google Scholar
  3. S. A. Joslyn, “Ductal carcinoma in situ: trends in geographic, temporal, and demographic patterns of care and survival,” Breast Journal, vol. 12, no. 1, pp. 20–27, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. G. L. Smith, B. D. Smith, and B. G. Haffty, “Rationalization and regionalization of treatment for ductal carcinoma in situ of the breast,” International Journal of Radiation Oncology Biology Physics, vol. 65, no. 5, pp. 1397–1403, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. L. J. Solin, A. Fourquet, F. A. Vicini et al., “Long-term outcome after breast-conservation treatment with radiation for mammographically detected ductal carcinoma in situ of the breast,” Cancer, vol. 103, no. 6, pp. 1137–1146, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Cutuli, R. Fay, C. Cohen-Solal-Le Nir et al., “Ductal carcinoma in situ of the breast: analysis of 882 cases,” Presse Medicale, vol. 33, no. 2, pp. 83–89, 2004. View at Google Scholar · View at Scopus
  7. C. Vargas, L. Kestin, N. Go et al., “Factors associated with local recurrence and cause-specific survival in patients with ductal carcinoma in situ of the breast treated with breast-conserving therapy or mastectomy,” International Journal of Radiation Oncology Biology Physics, vol. 63, no. 5, pp. 1514–1521, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. A. P. Schouten van der Velden, R. van Vugt, J. A. A. M. Van Dijck, J. W. H. Leer, and T. Wobbes, “Local recurrences after different treatment strategies for ductal carcinoma in situ of the breast: a population-based study in the East Netherlands,” International Journal of Radiation Oncology Biology Physics, vol. 69, no. 3, pp. 703–710, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. M. J. Silverstein, “The Van Nuys/University of Southern California experience by treatment,” in Ductal Carcinoma in Situ of the Breast, pp. 337–342, Lippincot Williams and Wilkins, Philadelphia, Pa, USA, 2nd edition, 2002. View at Google Scholar
  10. M. J. Silverstein, M. D. Lagios, P. H. Craig et al., “A prognostic index for ductal carcinoma in situ of the breast,” Cancer, vol. 77, no. 11, pp. 2267–2274, 1996. View at Google Scholar
  11. M. J. Silverstein, “The University of Southern California/Van Nuys prognostic index for ductal carcinoma in situ of the breast,” American Journal of Surgery, vol. 186, no. 4, pp. 337–343, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. I. De Mascarel, F. Bonichon, G. Macgrogan et al., “Application of the Van Nuys prognostic index in a retrospective series of 367 ductal carcinomas in situ of the breast examinated by serial macroscopic sectioning: Practical considerations,” Breast Cancer Research and Treatment, vol. 61, no. 2, pp. 151–159, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. S. G. MacAusland, J. T. Hepel, F. K. Chong et al., “An attempt to independently verify the utility of the Van Nuys Prognostic Index for ductal carcinoma in situ,” Cancer, vol. 110, no. 12, pp. 2648–2653, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Amichetti, O. Caffo, A. Richetti et al., “Ten-year results of treatment of ductal carcinoma in situ (DCIS) of the breast with conservative surgery and radiotherapy,” European Journal of Cancer, vol. 33, no. 10, pp. 1559–1565, 1997. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Amichetti, O. Caffo, A. Richetti et al., “Subclinical ductal carcinoma in situ of the breast: treatment with conservative surgery and radiotherapy,” Tumori, vol. 85, no. 6, pp. 488–493, 1999. View at Google Scholar · View at Scopus
  16. B. Fisher, S. Land, E. Mamounas, J. Dignam, E. R. Fisher, and N. Wolmark, “Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the National Surgical Adjuvant Breast and Bowel Project experience,” Seminars in Oncology, vol. 28, no. 4, pp. 400–418, 2001. View at Google Scholar · View at Scopus
  17. E. R. Fisher, J. Dignam, E. Tan-Chiu et al., “Pathologic Findings from the National Surgical Adjuvant Breast Project (NSABP) Eight-Year Update of Protocol B-17,” Cancer, vol. 86, no. 3, pp. 429–438, 1999. View at Google Scholar
  18. I. L. Wapnir, J. J. Dignam, B. Fisher et al., “Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS,” Journal of the National Cancer Institute, vol. 103, no. 6, pp. 478–488, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Bijker, P. Meijnen, J. L. Peterse et al., “Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: ten-year results of european organisation for research and treatment of cancer randomized phase III trial 10853—a study by the EORTC breast cancer cooperative group and EORTC radiotherapy group,” Journal of Clinical Oncology, vol. 24, no. 21, pp. 3381–3387, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Bijker, J. L. Peterse, J. P. Julien et al., “Risk factors for recurrence and metastasis after breast-conserving therapy for ductal carcinoma-in-situ: analysis of European Organization for Research and Treatment of Cancer Trial 10853,” Journal of Clinical Oncology, vol. 19, no. 8, pp. 2263–2271, 2001. View at Google Scholar · View at Scopus
  21. L. Holmberg, H. Garmo, B. Granstrand et al., “Absolute risk reductions for local recurrence after postoperative radiotherapy after sector resection for ductal carcinoma in situ of the breast,” Journal of Clinical Oncology, vol. 26, no. 8, pp. 1247–1252, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Ringberg, H. Nordgren, S. Thorstensson et al., “Histopathological risk factors for ipsilateral breast events after breast conserving treatment for ductal carcinoma in situ of the breast—results from the Swedish randomised trial,” European Journal of Cancer, vol. 43, no. 2, pp. 291–298, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. UK Coordinating Committee on Cancer Research Ductal Carcinoma in situ Working Party on behalf of DCIS trialists in the UK, Australia, and New Zealand, “Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ of the breast in the UK, Australia, and New Zealand: randomised controlled trial,” Lancet, vol. 362, pp. 95–102, 2003. View at Google Scholar
  24. J. Cuzick, I. Sestak, S. E. Pinder et al., “Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK/ANZ DCIS trial,” The Lancet Oncology, vol. 12, no. 1, pp. 21–29, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. G. A. Viani, E. J. Stefano, S. L. Afonso et al., “Breast-conserving surgery with or without radiotherapy in women with ductal carcinoma in situ: a meta-analysis of randomized trials,” Radiation Oncology, vol. 2, no. 1, article no. 28, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Goodwin, S. Parker, D. Ghersi, and N. Wilcken, “Post-operative radiotherapy for ductal carcinoma in situ of the breast—a systematic review of the randomised trials,” Breast, vol. 18, no. 3, pp. 143–149, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Goodwin, S. Parker, D. Ghersi, and N. Wilcken, “Post-operative radiotherapy for ductal carcinoma in situ of the breast,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD000563, 2009. View at Google Scholar · View at Scopus
  28. Early Breast Cancer Trialists' Collaborative Group (EBCTCG), “Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast,” Journal of the National Cancer Institute. Monographs, vol. 2010, no. 41, pp. 162–177, 2010. View at Google Scholar · View at Scopus
  29. L. L. Hughes, M. Wang, D. L. Page et al., “Local excision alone without irradiation for ductal carcinoma in situ of the breast: a trial of the Eastern Cooperative Oncology Group,” Journal of Clinical Oncology, vol. 27, no. 32, pp. 5319–5324, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. R. L. Balleine, L. R. Webster, S. Davis et al., “Molecular grading of ductal carcinoma in situ of the breast,” Clinical Cancer Research, vol. 14, no. 24, pp. 8244–8252, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Omlin, M. Amichetti, D. Azria et al., “Boost radiotherapy in young women with ductal carcinoma in situ: a multicentre, retrospective study of the Rare Cancer Network,” Lancet Oncology, vol. 7, no. 8, pp. 652–656, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Yerushalmi, A. Sulkes, M. Mishaeli et al., “Radiation treatment for ductal carcinoma in situ (DCIS): is a boost to the tumor bed necessary?” Neoplasma, vol. 53, no. 6, pp. 507–510, 2006. View at Google Scholar · View at Scopus
  33. T. B. Julian, S. R. Land, Y. Wang et al., “Is boost therapy necessary in the treatment of DCIS?” Journal of Clinical Oncology, vol. 26, abstract 537, 2008. View at Google Scholar
  34. A. Monteau, B. Sigal-Zafrani, Y. M. Kirova et al., “Ductal carcinoma in situ of the breast with close or focally involved margins following breast-conserving surgery: treatment with reexcision or radiotherapy with increased dosage,” International Journal of Radiation Oncology Biology Physics, vol. 75, no. 4, pp. 1021–1028, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. E. S. Wai, M. L. Lesperance, C. S. Alexander et al., “Effect of radiotherapy boost and hypofractionation on outcomes in ductal carcinoma in situ,” Cancer, vol. 117, no. 1, pp. 54–62, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. J. S. Wong, C. M. Kaelin, S. L. Troyan et al., “Prospective study of wide excision alone for ductal carcinoma in situ of the breast,” Journal of Clinical Oncology, vol. 24, no. 7, pp. 1031–1036, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Meijnen, H. S. A. Oldenburg, J. L. Peterse, H. Bartelink, and E. J. T. Rutgers, “Clinical outcome after selective treatment of patients diagnosed with ductal carcinoma in situ of the breast,” Annals of Surgical Oncology, vol. 15, no. 1, pp. 235–243, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. M. J. Silverstein, M. D. Lagios, S. Groshen et al., “The influence of margin width on local control of ductal carcinoma in situ of the breast,” New England Journal of Medicine, vol. 340, no. 19, pp. 1455–1461, 1999. View at Publisher · View at Google Scholar · View at Scopus
  39. C. Dunne, J. P. Burke, M. Morrow, and M. R. Kell, “Effect of margin status on local recurrence after breast conservation and radiation therapy for ductal carcinoma in situ,” Journal of Clinical Oncology, vol. 27, no. 10, pp. 1615–1620, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. L. J. Solin, A. Fourquet, F. A. Vicini et al., “Long-term outcome after breast-conservation treatment with radiation for mammographically detected ductal carcinoma in situ of the breast,” Cancer, vol. 103, no. 6, pp. 1137–1146, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. L. J. Solin, A. Fourquet, F. A. Vicini et al., “Salvage treatment for local or local-regional recurrence after initial breast conservation treatment with radiation for ductal carcinoma in situ,” European Journal of Cancer, vol. 41, no. 12, pp. 1715–1723, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Romestaing, Y. Lehingue, C. Carrie et al., “Role of a 10-Gy boost in the conservative treatment of early breast cancer: results of a randomized clinical trial in Lyon, France,” Journal of Clinical Oncology, vol. 15, no. 3, pp. 963–968, 1997. View at Google Scholar · View at Scopus
  43. H. Bartelink, J. C. Horiot, P. M. Poortmans et al., “Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-Year results of the randomized boost versus no boost EORTC 22881-10882 trial,” Journal of Clinical Oncology, vol. 25, no. 22, pp. 3259–3265, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. P. Wong, C. Lambert, R. V. Agnihotram, M. David, M. Duclos, and C. R. Freeman, “Ductal carcinoma in situ-the influence of the radiotherapy boost on local control,” International Journal of Radiation Oncology, Biology, Physics, vol. 82, no. 2, pp. e153–e158, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. C. Polgár, Z. Kahán, Z. Orosz et al., “The role of radiotherapy in the conservative treatment of ductal carcinoma in situ of the breast,” Pathology and Oncology Research, vol. 14, no. 2, pp. 179–192, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. D. Azria, H. Auvray, I. Barillot et al., “Radiothérapie des carcinomes canalaires in situ: impact du complément d’irradiation du lit tumoral,” Cancer/Radiothérapie, vol. 12, no. 6-7, pp. 571–576, 2008. View at Google Scholar
  47. T. J. Whelan, D. H. Kim, and J. Sussman, “Clinical experience using hypofractionated radiation schedules in breast cancer,” Seminars in Radiation Oncology, vol. 18, no. 4, pp. 257–264, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. G. M. Freedman, P. R. Anderson, L. J. Goldstein et al., “Four-week course of radiation for breast cancer using hypofractionated intensity modulated radiation therapy with an incorporated boost,” International Journal of Radiation Oncology Biology Physics, vol. 68, no. 2, pp. 347–353, 2007. View at Publisher · View at Google Scholar · View at Scopus
  49. C. Constantine, P. Parhar, S. Lymberis et al., “Feasibility of accelerated whole-breast radiation in the treatment of patients with ductal carcinoma in situ of the breast,” Clinical Breast Cancer, vol. 8, no. 3, pp. 269–274, 2008. View at Publisher · View at Google Scholar · View at Scopus
  50. L. Livi, M. Stefanacci, S. Scoccianti et al., “Adjuvant hypofractionated radiation therapy for breast cancer after conserving surgery,” Clinical Oncology (Royal College of Radiologists), vol. 19, no. 2, pp. 120–124, 2007. View at Google Scholar
  51. D. Williamson, R. Dinniwell, S. Fung, M. Pintilie, S. J. Done, and A. W. Fyles, “Local control with conventional and hypofractionated adjuvant radiotherapy after breast-conserving surgery for ductal carcinoma in-situ,” Radiotherapy and Oncology, vol. 95, no. 3, pp. 317–320, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. M. J. Silverstein, Ductal Carcinoma in Situ of the Breast, Lippincot Williams and Wilkins, Philadelphia, Pa, USA, 2nd edition, 2002.
  53. B. D. Smith, D. W. Arthur, T. A. Buchholz et al., “Accelerated partial breast irradiation Consensus Statement from the American Society for Radiation Oncology (ASTRO),” International Journal of Radiation Oncology Biology Physics, vol. 74, no. 4, pp. 987–1001, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. S. S. Park, I. S. Grills, P. Y. Chen et al., “Accelerated partial breast irradiation for pure ductal carcinoma in situ,” International Journal of Radiation Oncology, Biology, and Physics, vol. 81, no. 2, pp. 403–408, 2011. View at Google Scholar
  55. J. S. Jeruss, H. M. Kuerer, P. D. Beitsch, F. A. Vicini, and M. Keisch, “Update on DCIS outcomes from the american society of breast surgeons accelerated partial breast irradiation registry trial,” Annals of Surgical Oncology, vol. 18, no. 1, pp. 65–71, 2011. View at Publisher · View at Google Scholar · View at Scopus