International Journal of Surgical Oncology / 2012 / Article / Tab 3

Research Article

Parathyroid Carcinoma: The Importance of High Clinical Suspicion for a Correct Management

Table 3

Typical features of PHPT secondary to parathyroid carcinoma versus parathyroid benign disease.

Parathyroid carcinomaParathyroid benign disease

Average age4855
Female/male ratio1 : 13,5 : 1
Tumor size >3 cmFrequentVery rare
Serum calcium14–16 mg/dL11-12 mg/dL
PTHMarkedly elevatedMildly elevated
Asymptomatic<2%40–80%
Palpable neck mass38%<2%
Hoarseness1–14%None
Renal and skeletal involvement30–50%<5%
Hypercalcemic crisis14%<2%
Intraoperative findingsLobulated firm mass, surrounded by fibrous grayish-white capsule that adheres tenaciously to thyroid lobe or adjacent cervical tissuesSoft, oval, and brownish red

(From ref. [13, 6, 9, 10]).

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