Radical Prostatectomy as a First-Line Treatment in Patients with Initial PSA  >20 ng/mL

Table 4

Univariate and multivariate analysis of pathologic variables.

Parameter	Univariate analysis	Multivariate analysis
	P value	P value	HR^* (95% CI^**)
Age (years)	0.164	0.506	—
Initial PSA (ng/mL)	0.042	0.116	—
cT (cT1 versus cT2 versus cT3)	0.003	0.806	—
Gleason score (<7 versus 7 versus >7)	0.002	0.065	—
pT (pT2 versus pT3 versus pT4)	<0.001	0.009	3.515 (1.882–6.565)
Seminal vesicle invasion (yes versus no)	0.006	0.932	—
Surgical margins (neg. versus pos.)	0.003	0.084	—
Lymph node status (N0 versus N1)	<0.001	0.034	1.002 (1.000–1.003)
Adjuvant radiotherapy (yes versus no)	0.968	0.506	—
Adjuvant hormonal therapy (yes versus no)	0.023	0.105	—

^*HR: hazard ratio; ^**CI: confidence interval.