Resection of Nonalcoholic Steatohepatitis-Associated Hepatocellular Carcinoma: A Western Experience
Figure 2
Histopathological features of noncirrhotic NASH-associated HCC. (a) The nonneoplastic liver shows macrovesicular steatosis involving the perivenular zone (*) with sparing of the periportal zones (arrowheads) (patient 8, H&E stain, 40x). (b) and (c) show at greater magnification the steatotic hepatocytes (arrows) and ballooning degeneration of hepatocytes (arrowheads) evident in the perivenular zone of the nonneoplastic parenchyma (patients 4 and 7, H&E stain, 100x and 200x). (d) Specialized collagen staining shows the central venule (*) to be invested with a band of perivenular fibrosis; bridging fibrosis and cirrhotic nodules are notably absent (patient 7, Masson’s trichrome stain, 200x). (e) and (f) show two examples of HCC arising within noncirrhotic NASH showing pseudoglandular (arrowheads) and trabecular (arrows) features and fat within tumor cells (right frame) (patients 7 and 8, H&E stain, 100x).
