Oncologic Safety of Skin-Sparing and Nipple-Sparing Mastectomy: A Discussion and Review of the Literature

Table 4

Local and nipple areolar complex recurrence after nipple-sparing mastectomy.

Author	Study design	Number of Pts	LR	NAC recurrence	Median followup (months)
Gerber et al. [17]	Prospective	112	5.4% NSM, 8.2% MRM (𝑃=0.6)	0.9%	59
Petit et al. [16]	Prospective	27	0.00%	0	6
Caruso et al. [20]	Prospective	50	2%	2%	66
Sacchini et al. [21]	Retrospective	192	3%	0	24.6
Petit et al. [19]	Prospective	106	1%	0	13
Benediktsson and Perbeck [73]	Prospective	216	20.8%	0	156
Regolo et al. [23]	Retrospective	102	0	0	16
Petit et al. [27]	Prospective	579	2.40%	0	19
Crowe et al. [22]	Prospective	149	1.30%	0	41
Sookhan et al. [26]	Retrospective	18	0	0	10.8
Voltura et al. [30]	Retrospective	51	5.9	0	18
Garwood et al. [31]	Prospective	102	0.6%	0	13
Gerber et al. [74]	Prospective	112^*	11.7% NSM, 10.4% SSM, 11.5% MRM (𝑃=0.974)	0.9%	101
Garcia-Etienne et al. [32]	Retrospective	42 NSM	0	0	10
Paepke et al. [28]	Retrospective	96	2%	0	34
De Alcantara Filho et al. [29]	Prospective	353	0	0	10.4
Petit et al. [75]	Prospective	934	4%	1.18%	50