Cell Polarity, Epithelial-Mesenchymal Transition, and Cell-Fate Decision Gene Expression in Ductal Carcinoma In Situ

Table 1

Differentially expressed genes between ADH or DCIS and histologically normal (HN) tissue (ordered according to 𝑃 value).

ADH versus HN			DCIS versus HN
Gene symbol	𝑃 value	Variation	Gene symbol	𝑃 value	Variation
JAM3	0.000045	↓	JAM3	0.000016	↓
JAG2	0.000337	↓	EGFR	0.000103	↓
CD24	0.000364	↑	SNAI2	0.000127	↓
SNAI2	0.000594	↓	CLDN5	0.000136	↓
EGFR	0.001897	↓	JAM2	0.000150	↓
FOXC1	0.002222	↓	FOXC1	0.000167	↓
EGF	0.003163	↓	CD24	0.000277	↑
ID2	0.003547	↑	JAG2	0.000297	↓
JAM2	0.005052	↓	KRT5	0.000420	↓
TJP3	0.005070	↑	KRT14	0.000425	↓
TGFBR3	0.005537	↓	GATA3	0.000490	↑
KRT17	0.005624	↓	TGFBR3	0.000710	↓
GATA3	0.005795	↑	TJP3	0.001046	↑
TP53	0.006737	↑	KRT17	0.001402	↓
CDH4	0.006916	↓	SOX4	0.001942	↑
AKT1	0.009044	↑	AKT1	0.002867	↑
CLDN7	0.012026	↑	CLDN8	0.003090	↓
EPCAM	0.015207	↑	CDC42	0.003643	↑
ABCG2	0.019210	↓	EGF	0.003752	↓
KRT5	0.019854	↓	EPCAM	0.004605	↑
KRT14	0.020117	↓	CLDN7	0.004749	↑
CLDN11	0.023005	↓	ESR1	0.007188	↑
PARD3	0.030202	↓	DLG1	0.007249	↑
SOX4	0.036127	↑	KRT19	0.007637	↑
CDC42	0.036404	↑	FOXA1	0.007844	↑
TIAM1	0.038034	↑	KRT18	0.010091	↑
ESR1	0.038527	↑	CDH3	0.010638	↓
PVR	0.039104	↓	TIAM1	0.010722	↑
			TGFBR2	0.013243	↓
			RHOA	0.013540	↑
			BRCA1	0.014098	↑
			ID4	0.017030	↓
			ID2	0.018115	↑
			NOTCH4	0.018550	↓
			PVRL2	0.019914	↑
			AKT3	0.020275	↓
			ACTN1	0.020619	↓
			PROM1	0.022238	↓
			CDH4	0.022933	↓
			DLG3	0.023798	↑
			F11R	0.031657	↑
			CTNNA1	0.033234	↑
			MTA2	0.033999	↓
			ABCG2	0.037966	↓
			MPP5	0.039023	↑
			HIF1A	0.039489	↑
			CDKN1A	0.047769	↑

In bold, genes with an estimated FDR < 0.01.