TY - JOUR
A2 - Hünerbein, Michael
AU - Mirza, A.
AU - Pritchard, S.
AU - Welch, I.
PY - 2013
DA - 2013/09/17
TI - The Postoperative Component of MAGIC Chemotherapy Is Associated with Improved Prognosis following Surgical Resection in Gastric and Gastrooesophageal Junction Adenocarcinomas
SP - 781742
VL - 2013
AB - Aims. MAGIC chemotherapy has become the standard of treatment for patients undergoing curative resection for gastric and gastrooesophageal junction (GOJ) cancers. The importance of postoperative component of this regimen is uncertain. The aim of this study was to compare survival and cancer recurrence in patients who have received neoadjuvant and adjuvant chemotherapies according to MAGIC protocol with those patients completing only neoadjuvant chemotherapy. Methods. 66 patients with gastric and GOJ adenocarcinomas treated with neoadjuvant and adjuvant chemotherapies according to the MAGIC protocol were studied. All patients underwent potentially curative surgical resection. The histological, demographic, and survival data were collected for all patients. Results. The median number of neoadjuvant chemotherapy cycles received was 2 (range 1–3). Thirty-one (47%) patients underwent adjuvant chemotherapy with a median of 2 cycles (range 1–3). Patients who have completed both cycles of chemotherapy had significantly improved survival (P=0.04). Patients with involved lymph nodes and positive longitudinal resection margins had increased incidence of recurrence (P=0.02) and poor five-year survival (P=0.03). Conclusions. Patients who received both neoadjuvant and adjuvant chemotherapies for gastric and gastro-oesophageal junction tumours have improved outcomes compared to patients who only received neoadjuvant chemotherapy.
SN - 2090-1402
UR - https://doi.org/10.1155/2013/781742
DO - 10.1155/2013/781742
JF - International Journal of Surgical Oncology
PB - Hindawi Publishing Corporation
KW -
ER -