Genetic Heterogeneity of Breast Cancer Metastasis May Be Related to miR-21 Regulation of TIMP-3 in Translation

Table 1

Grouped criteria	High invasion and metastasis group HIMG	Low invasion and metastasis group LIMG
Diameter by ultrasound (cm)	<2 cm	≧3 cm
Lymph nodes metastasis by HE	Yes	No
Micrometastasis by CK-22	Unnecessary	No
Histological grading	III	I
Tumor embolus	Positive	Negative
Her2 receptor status	Positive	Negative
ER & PR	Negative	Positive
P53	Positive	Negative
Ki67	≧14%	<14%

All indicators of immunohistochemical staining need to meet verification of two pathological diagnosis centers.