International Journal of Surgical Oncology

Review Article

The Treatment of Peritoneal Carcinomatosis in Advanced Gastric Cancer: State of the Art

Table 2

Comparing main meta-analysis in terms of overall survival and morbidity.


Authors	Year published	Type of study	Stage of GC	Number of patients	Type of protocol	Overall survival	Peritoneal recurrence	Mortality and morbidity

Yan et al. [11]	2007	Meta-analysis (13 RCTs)	Stage I–IV	1648	Surgery + HIPEC/HIPEC + EPIC/NIIC versus surgery alone ± systemic chemotherapy	HR = 0.60¹ HR = 0.45² HR = 0.67³	RR = 0.84 RR = 0.51 RR = 1.00	RR = 1.43 RR = 1.01/1.81/0.76/2.37/4.33^#
Jin-Yu et al. [12]	2012	Meta-analysis (15 RCTs)	N/A	1713	HIPEC versus HIPEC + PIC versus NIIC	HR = 0.60 HR = 0.47 HR = 0.70	OR = 0.69	OR = 2.29 OR = 1.04/2.60/1.61/0.39/5.74/3.67/3.57^$
Sun et al. [13]	2012	Meta-analysis (10 RCTs)	Stage II-III	1062	HIPEC* versus surgery	MMC RR = 0.75 5-FU RR = 0.69	RR = 0.45	N/A for Mortality RR = 1.68/0.52/1.38/0.79/1.47^£

HR: hazard ratio; RR: risk ratio; OR: odds ratio; MMC: mitomycin C; 5-FU: 5-fluorouracil; HIPEC: hyperthermic intraperitoneal chemotherapy; EPIC: early postoperative intraperitoneal chemotherapy; PIC: perioperative intraperitoneal chemotherapy; NIC: NIIC: normothermic intraoperative intraperitoneal chemotherapy; RCS: retrospective case series; PCS: prospective case series; N/A: not available; PC: peritoneal carcinomatosis.
^1,2,3HIPEC, HIPEC + EPIC, and NIIC, respectively.
No differences in morbidity between HIPEC and NIIC groups and the respective control arms.
^#Morbidity of anastomotic leak, bowel fistula, pancreatic fistula, intra-abdominal abscess, and neutropenia, respectively.
*Data calculated with risk ratio (RR) and divided in two subgroups for analysis: mitomycin C subgroup RR = 0.75, 5-Fluorouracil RR = 0.69 versus control group RR = 0.45.
^£Morbidity of bone marrow suppression, anastomotic leak, bowel fistula, adhesive ileus, and liver disfunction, respectively.
^$Morbidity of anastomotic leak, ileus, bowel perforation, pancreatic fistula, marrow depression, fever, and intra-abdominal abscess, respectively.