Table 4: Univariate and multivariate analysis of disease-free survival.

CharacteristicsUnivariateMultivariate
HR95% CI valueHR95% CI value

Low-volume surgeon4451.0001.000
High-volume surgeon3160.5660.44–0.74<0.0010.7360.55–0.980.04

Age in years0.01<0.001
 <50411.0001.000
 50–754861.0520.61–1.801.2610.67–2.37
 >752341.3041.16–1.492.0341.01–4.08

ASA-classification [16]<0.0010.05
 11581.0001.000
 24100.9380.68–1.290.9140.63–1.33
 31811.5471.09–2.191.3010.86–1.97
 4252.5671.65–4.621.5071.05–2.86

Urogenital comorbidity 661.5211.07–2.170.021.1740.69–1.470.43

Open surgical technique 2531.0001.000
Laparoscopic5080.5180.41–0.65<0.0010.7520.55–1.030.08

No conversion 3961.0001.000
Conversion (laparoscopy only)1121.3801.03–1.860.031.3370.92–1.950.13

Elapsed time of the surgery 7611.0031.00–1.010.021.0010.99–1.010.43

Blood loss intraoperatively7611.0011.00–1.01<0.0011.0000.99–1.000.20

Tumor stage<0.0010.04
 1501.0001.000
 21531.2930.63–2.671.3070.59–2.91
 34892.5491.31–4.971.6660.79–3.52
 4586.6093.21–13.62.8141.21–6.54

Nodal stage<0.001<0.001
 04391.0001.000
 12162.4841.91–3.231.7691.28–2.46
 21064.7913.57–6.432.4841.51–4.10

Metastatic stage<0.001<0.001
 06841.0001.000
 1779.6977.29–12.97.0934.99–10.1

Positive lymph nodes7611.1171.09–1.14<0.0011.0310.98–1.080.21

Resection margins<0.0010.29
 Complete resection (R0)7311.0001.000
 Microscopically irradical (R1)192.9551.76–4.971.2000.60–2.38
 Macroscopically irradical (R2)113.0801.58–6.000.5510.23–1.32

Length of hospital-stay7611.0121.01–1.02<0.0011.0040.99–1.010.39

No adverse event6561.0001.000
Adverse event1051.6641.24–2.230.011.0690.69–1.650.76

No adjuvant chemotherapy5461.0001.000
Adjuvant chemotherapy2152.1041.67–2.65<0.0011.3760.98–1.930.06

Only significant factors listed; 13 patients lost to follow-up, 8 low-volume patients, and 5 high-volume patients; according to the AJCC TNM-staging system [17].