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International Journal of Surgical Oncology
Volume 2015, Article ID 901046, 7 pages
Review Article

Contralateral Risk-Reducing Mastectomy: Review of Risk Factors and Risk-Reducing Strategies

1Nightingale and Genesis Prevention Centre, University Hospital South Manchester, Southmoor Road, Manchester M23 9LT, UK
2Department of Breast Surgery, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
3The Institute of Cancer Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, UK
4University of Manchester Department of Genomic Medicine, Institute of Human Development, St. Mary’s Hospital, Oxford Road, Manchester M13 9WL, UK

Received 20 August 2014; Revised 2 January 2015; Accepted 9 January 2015

Academic Editor: Kazuhiro Yoshida

Copyright © 2015 N. N. Basu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Rates of contralateral risk-reducing mastectomy have increased substantially over the last decade. Surgical oncologists are often in the frontline, dealing with requests for this procedure. This paper reviews the current evidence base regarding contralateral breast cancer, assesses the various risk-reducing strategies, and evaluates the cost-effectiveness of contralateral risk-reducing mastectomy.