Research Article

Preoperative Radiation Therapy Followed by Reexcision May Improve Local Control and Progression-Free Survival in Unplanned Excisions of Soft Tissue Sarcomas of the Extremity and Chest-Wall

Table 1

Patient, disease, and treatment characteristics between patients who underwent UE and PE.

VariableAll patientsPlanned excisionUnplanned excision

Number24521134

Median age575764

Median tumor Size7.9 cm8.5 cm4 cm

StageI: 46 (18.7%)
II: 62 (25.3%)
III: 137 (56%)
I: 40 (19%)
II: 46 (22%)
III: 125 (59%)
I: 6 (17.7%)
II: 16 (47%)
III: 12 (35.3%)

GradeLow: 47 (19.1%)
Intermediate: 20 (8.2%)
High: 178 (72.7%)
Low: 45 (18.4%)
Intermediate: 15 (6.1%)
High: 185 (75.5%)
Low: (3%)
Intermediate: 5 (14.7%)
High: 28 (82.3%)

HistologyUndifferentiated: 56 (22.9%)
Leiomyosarcoma/liposarcoma: 77 (31.4%)
Synovial: 45 (18.4%)
Other: 67 (27.3%)
Undifferentiated: 51 (24.1%)
Leiomyosarcoma/liposarcoma: 68 (32.2%)
Synovial: 38 (18%)
Other: 48 (22.7%)
Undifferentiated: 6 (17.6%)
Leiomyosarcoma/liposarcoma: 9 (26.5%)
Synovial: 7 (20.6%)
Other: 12 (35.3%)

Tumor locationUpper extremity: 64 (26.1%)
Lower extremity: 181 (73.9%)
Upper extremity: 50 (23.7%)
Lower extremity: 161 (76.3%)
Upper extremity: 13 (38.2%)
Lower extremity: 21 (61.8%)

Subcutaneous disease (TXa)45 (18.4%)36 (17%)9 (26.5%)

Timing of RTNo RT: 36 (14.7%)
Preoperative: 174 (71%)
Postoperative: 35 (14.3%)
No RT: 24 (11.4%)
Preoperative: 163 (77.2%)
Postoperative: 24 (11.4%)
No RT: 12 (35.4%)
Preoperative: 11 (32.3%)
Postoperative (alone or after reexcision): 11 (32.3%)

Chemotherapy68 (28%)67 (32%)1 (3%)