International Journal of Surgical Oncology

Surgical Margins in Breast Conservation

Publishing date
28 Dec 2012
Submission deadline
10 Aug 2012

1Division of Breast Surgery, Columbia University Medical Center, New York, NY, USA

2Breakthrough Research Unit, Edinburgh Breast Unit, Western General Hospital, Edinburgh, UK

3Department of Breast Services, Cleveland Clinic Foundation, Cleveland, OH, USA

4Division of Breast Surgery, Breast Center, Kameda Medical Center, 929 Higashi-cho, Kamogawa 296-8602, Japan

Surgical Margins in Breast Conservation


Historically, clear surgical margins have been regarded as essential in minimizing local recurrence rates for breast cancer. As systemic therapies have improved and emerging therapies are changing the future of breast cancer care, the relevance of surgical margins is no longer so obvious. There is still no consensus regarding the definition of a clear margin, and preoperative imaging lacks the ability to delineate borders of most tumors. Intraoperative margin assessment is limited, and no consensus on pathologic evaluation of margins exists. The quest for wider margins comes at the cost of suboptimal cosmetic results, increased reexcision rates, or larger surgical procedures involving the contralateral breast. Patient and tumor factors as well as adjuvant therapies may be as important as surgical margins in achieving acceptable local recurrence rates. Newer ablative therapies provide a means to obtain local control without necessarily surgically clearing a margin.

We invite investigators to contribute original research articles as well as review articles that will help to further elucidate the importance of surgical margins in achieving acceptable local recurrence rates in this era of improved adjuvant therapy for breast cancer. Potential topics include, but are not limited to:

  • Preoperative imaging strategies to define tumor boundaries
  • Novel technology for intraoperative margin assessment
  • Intraoperative and postoperative strategies for accurate pathologic margin assessment
  • Preoperative definition and implications of margins in the setting of neoadjuvant chemotherapy
  • Role of ablative therapies in lumpectomy cavity to increase tumor-free margins
  • Role of quadrantectomy and oncoplastic surgery in achieving negative margins
  • Relative importance of surgical clearance of margins versus adjuvant therapies

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


  • Special Issue
  • - Volume 2013
  • - Article ID 136387
  • - Editorial

Surgical Margins in Breast Conservation

Sheldon Marc Feldman
  • Special Issue
  • - Volume 2012
  • - Article ID 868623
  • - Clinical Study

Analysis of the Impact of Intraoperative Margin Assessment with Adjunctive Use of MarginProbe versus Standard of Care on Tissue Volume Removed

Ronald J. Rivera | Dennis R. Holmes | Lorraine Tafra
  • Special Issue
  • - Volume 2012
  • - Article ID 861257
  • - Research Article

Assessing Breast Cancer Margins Ex Vivo Using Aqueous Quantum-Dot-Molecular Probes

Giang H. T. Au | Wan Y. Shih | ... | Ari D. Brooks
  • Special Issue
  • - Volume 2012
  • - Article ID 585670
  • - Review Article

Optimizing Surgical Margins in Breast Conservation

Preya Ananthakrishnan | Fatih Levent Balci | Joseph P. Crowe
  • Special Issue
  • - Volume 2012
  • - Article ID 297832
  • - Review Article

Atypical Ductal Hyperplasia at the Margin of Lumpectomy Performed for Early Stage Breast Cancer: Is there Enough Evidence to Formulate Guidelines?

Jennifer L. Baker | Farnaz Hasteh | Sarah L. Blair
  • Special Issue
  • - Volume 2012
  • - Article ID 180259
  • - Review Article

Evaluation of Resection Margins in Breast Conservation Therapy: The Pathology Perspective—Past, Present, and Future

Rajyasree Emmadi | Elizabeth L. Wiley
  • Special Issue
  • - Volume 2012
  • - Article ID 907576
  • - Review Article

Oncoplastic Breast Reduction: Maximizing Aesthetics and Surgical Margins

Michelle Milee Chang | Tara Huston | ... | Christine Rohde
International Journal of Surgical Oncology
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