The Use of a Green Fluorescent Protein Porcine Model to Evaluate Host Tissue Integration into Extracellular Matrix Derived Bionanocomposite Scaffolds

Table 2

Qualitative and quantitative histological scoring results.

Scaffold type	Cellular infiltration	Multinucleated giant cells (MNGC)	Vascularity	Connective tissue organization	Fibrous encapsulation	Scaffold degradation
Cross-linked
1 month	2.10 ± 0.49	0.03 ± 0.03	0.23 ± 0.12	1.00 ± 0.00	1.33 ± 0.33	1.00 ± 0.00
3 months	2.00 ± 0.71	0.00 ± 0.00	0.40 ± 0.15	1.33 ± 0.33	2.00	1.00 ± 0.00
6 months	2.38 ± 0.38	0.15 ± 0.10	1.13 ± 0.21	2.00 ± 0.58	—	1.5 ± 0.29
AuNP
1 month	1.67 ± 0.34	0.07 ± 0.03	0.03 ± 0.07	1.00 ± 0.00	2.00 ± 0.00	1.00 ± 0.00
3 months	1.13 ± 0.52	0.20 ± 0.20	0.40 ± 0.12	1.33 ± 0.33	2.00 ± 0.00	1.00 ± 0.00
6 months	2.46 ± 0.33	0.00 ± 0.00	1.27 ± 0.43	2.00 ± 0.00	—	1.00 ± 0.00
AuNP + nano-HAp
1 month	1.70 ± 1.00	0.00 ± 0.00	0.35 ± 0.05	1.00 ± 0.00	1.00 ± 0.00	1.00 ± 0.00
3 months	1.75 ± 0.85	0.20 ± 0.20	0.55 ± 0.35	2.00 ± 0.00	2.00	1.00 ± 0.00
6 months	1.91 ± 0.24	0.13 ± 0.13	1.06 ± 0.13	2.33 ± 0.33	—	1.67 ± 0.33

Scores are given as mean ± standard error of the mean. .