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International Journal of Vascular Medicine
Volume 2010, Article ID 430318, 4 pages
http://dx.doi.org/10.1155/2010/430318
Review Article

Plasmacytoid Dendritic Cells: From Heart to Vessels

Pharmaceutical Science Department, University of Salerno, 84084 Fisciano, Italy

Received 6 February 2010; Revised 29 June 2010; Accepted 30 August 2010

Academic Editor: C. Diehm

Copyright © 2010 Rosalinda Sorrentino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cardiovascular diseases, formerly only attributed to the alterations of the stromal component, are now recognized as immune-based pathologies. Plasmacytoid Dendritic Cells (pDCs) are important immune orchestrators in heart and vessels. They highly produce IFN type I that promote the polarization of T cells towards a Th1 phenotype; however, pDCs can also participate to suppressive networks via the recruitment of T regulatory cells that downmodulate proinflammatory responses. pDCs populate the vessel wall layers during pathological conditions, such as atherosclerosis. It is thus clear that a better identification of pDCs activity in cardiovascular diseases can not only elucidate pathological mechanisms but also lead to new therapeutic approaches.