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International Journal of Vascular Medicine
Volume 2010, Article ID 437809, 7 pages
http://dx.doi.org/10.1155/2010/437809
Review Article

Atherogenic Factors and Their Epigenetic Relationships

1Hemostasia and Vascular Genetics Laboratory, Biophysics and Biochemistry Center, Venezuelan Institute for Scientific Research IVIC, Carretera Panamericana km11, P.O. 26973, Caracas 1020, Venezuela
2Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, Australia

Received 23 June 2010; Accepted 25 August 2010

Academic Editor: Aaron S. Dumont

Copyright © 2010 Ana Z. Fernandez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. M. Morrison, S. A. Atkinson, S. Yusuf et al., “The Family Atherosclerosis Monitoring In earLY life (FAMILY) study. Rationale, design, and baseline data of a study examining the early determinants of atherosclerosis,” American Heart Journal, vol. 158, no. 4, pp. 533–539, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. D. X.-F. Deng, J. M. Spin, A. Tsalenko et al., “Molecular signatures determining coronary artery and saphenous vein smooth muscle cell phenotypes: distinct responses to stimuli,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 5, pp. 1058–1065, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. D. Won, S.-N. Zhu, M. Chen et al., “Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow,” American Journal of Pathology, vol. 171, no. 5, pp. 1691–1704, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. A. Bird, “Perceptions of epigenetics,” Nature, vol. 447, no. 7143, pp. 396–398, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. A. J. Lusis, “Atherosclerosis,” Nature, vol. 407, no. 6801, pp. 233–241, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. P. Libby, P. M. Ridker, and A. Maseri, “Inflammation and atherosclerosis,” Circulation, vol. 105, no. 9, pp. 1135–1143, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Iiyama, L. Hajra, M. Iiyama et al., “Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation,” Circulation Research, vol. 85, no. 2, pp. 199–207, 1999. View at Google Scholar · View at Scopus
  8. C. P. Regan, P. J. Adam, C. S. Madsen, and G. K. Owens, “Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury,” Journal of Clinical Investigation, vol. 106, no. 9, pp. 1139–1147, 2000. View at Google Scholar · View at Scopus
  9. C. Napoli, F. P. D'Armiento, F. P. Mancini et al., “Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions,” Journal of Clinical Investigation, vol. 100, no. 11, pp. 2680–2690, 1997. View at Google Scholar · View at Scopus
  10. M. D. Shahbazian and M. Grunstein, “Functions of Site-Specific histone acetylation and deacetylation,” Annual Review of Biochemistry, vol. 76, pp. 75–100, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. C. D. Allis, T. Jenuwein, and D. Reinberg, “Overview and concepts,” in Epigenetics, C. D. Allis, T. Jenuwein, and D. Reinberg, Eds., chapter 3, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, USA, 2009. View at Google Scholar
  12. S. Pradhan, H. G. Chin, P. -O. Estève, and S. E. Jacobsen, “SET7/9 mediated methylation of non-histone proteins in mammalian cells,” Epigenetics, vol. 4, no. 6, pp. 383–387, 2009. View at Publisher · View at Google Scholar
  13. W. Chen, M. Bacanamwo, and D. G. Harrison, “Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription,” Journal of Biological Chemistry, vol. 283, no. 24, pp. 16293–16298, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. A. V. Bieliauskas and M. K. H. Pflum, “Isoform-selective histone deacetylase inhibitors,” Chemical Society Reviews, vol. 37, no. 7, pp. 1402–1413, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. K. Garber, “HDAC inhibitors overcome first hurdle,” Nature Biotechnology, vol. 25, no. 1, pp. 17–19, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. A. Karytinos, F. Forneris, A. Profumo et al., “A novel mammalian flavin-dependent histone demethylase,” Journal of Biological Chemistry, vol. 284, no. 26, pp. 17775–17782, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. M. G. Goll and T. H. Bestor, “Eukaryotic cytosine methyltransferases,” Annual Review of Biochemistry, vol. 74, pp. 481–514, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. X. Wang, N. Ishimori, R. Korstanje, J. Rollins, and B. Paigen, “Identifying novel genes for atherosclerosis through mouse-human comparative genetics,” American Journal of Human Genetics, vol. 77, no. 1, pp. 1–16, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. D. Shiftman, S. G. Ellis, C. M. Rowland et al., “Identification of four gene variants associated with myocardial infarction,” American Journal of Human Genetics, vol. 77, no. 4, pp. 596–605, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. D. A. Hägg, M. Jernås, O. Wiklund et al., “Expression profiling of macrophages from subjects with atherosclerosis to identify novel susceptibility genes,” International Journal of Molecular Medicine, vol. 21, no. 6, pp. 697–704, 2008. View at Google Scholar · View at Scopus
  21. D. Steinberg, “An interpretive history of the cholesterol controversy, part III: mechanistically defining the role of hyperlipidemia,” Journal of Lipid Research, vol. 46, no. 10, pp. 2037–2051, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. C. R. Sirtori and R. Fumagalli, “LDL-cholesterol lowering or HDL-cholesterol raising for cardiovascular prevention: a lesson from cholesterol turnover studies and others,” Atherosclerosis, vol. 186, no. 1, pp. 1–11, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. F. E. Alkemade, P. Van Vliet, P. Henneman et al., “Prenatal Exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature,” American Journal of Pathology, vol. 176, no. 2, pp. 542–548, 2010. View at Publisher · View at Google Scholar · View at PubMed
  24. L. Brattstrom and D. E. L. Wilcken, “Homocysteine and cardiovascular disease: cause or effect?” American Journal of Clinical Nutrition, vol. 72, no. 2, pp. 315–323, 2000. View at Google Scholar · View at Scopus
  25. J. Joseph, D. E. Handy, and J. Loscalzo, “Quo vadis: whiter homocysteine research?” Cardiovascular Toxicology, pp. 1–11, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. R. de Franchis, I. Fermo, G. Mazzola et al., “Contribution of the cystathionine β-synthase gene (844ins68) polymorphism to the risk of early-onset venous and arterial occlusive disease and of fasting hyperhomocysteinemia,” Thrombosis and Haemostasis, vol. 84, no. 4, pp. 576–582, 2000. View at Google Scholar · View at Scopus
  27. M. Gaustadnes, N. Rüdiger, K. Rasmussen, and J. Ingerslev, “Intermediate and severe hyperhomocysteinemia with thrombosis: a study of genetic determinants,” Thrombosis and Haemostasis, vol. 83, no. 4, pp. 554–558, 2000. View at Google Scholar · View at Scopus
  28. M. G. Andreassi, N. Botto, F. Cocci et al., “Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease,” Human Genetics, vol. 112, no. 2, pp. 171–177, 2003. View at Google Scholar
  29. J. Yideng, Z. Jianzhong, H. Ying et al., “Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs,” DNA and Cell Biology, vol. 26, no. 8, pp. 603–611, 2007. View at Publisher · View at Google Scholar · View at PubMed
  30. M. S. Jamaluddin, I. Chen, F. Yang et al., “Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene,” Blood, vol. 110, no. 10, pp. 3648–3655, 2007. View at Publisher · View at Google Scholar · View at PubMed
  31. J. Yideng, L. Zhihong, X. Jiantuan, C. Jun, L. Guizhong, and W. Shuren, “Homocysteine-mediated PPARα,γ DNA methylation and its potential pathogenic mechanism in monocytes,” DNA and Cell Biology, vol. 27, no. 3, pp. 143–150, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. A. Bowie and L. A. J. O'Neill, “Oxidative stress and nuclear factor-κB activation: a reassessment of the evidence in the light of recent discoveries,” Biochemical Pharmacology, vol. 59, no. 1, pp. 13–23, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. P. J. Barnes and M. Karin, “Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases,” New England Journal of Medicine, vol. 336, no. 15, pp. 1066–1071, 1997. View at Publisher · View at Google Scholar
  34. Y. Li, M. A. Reddy, F. Miao et al., “Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-κB-dependent inflammatory genes: relevance to diabetes and inflammation,” Journal of Biological Chemistry, vol. 283, no. 39, pp. 26771–26781, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. D. Brasacchio, J. Okabe, C. Tikellis et al., “Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail,” Diabetes, vol. 58, no. 5, pp. 1229–1236, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. Y. Higashi, K. Noma, M. Yoshizumi, and Y. Kihara, “Endothelial function and oxidative stress in cardiovascular diseases,” Circulation Journal, vol. 73, no. 3, pp. 411–418, 2009. View at Publisher · View at Google Scholar
  37. I. Fridovich, “Oxidative stress,” in Encyclopedia of Life Sciences (ELS), John Wiley & Sons, Chichester, UK, 2009. View at Google Scholar
  38. H. Cai and D. G. Harrison, “Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress,” Circulation Research, vol. 87, no. 10, pp. 840–844, 2000. View at Google Scholar · View at Scopus
  39. U. Singh and I. Jialal, “Oxidative stress and atherosclerosis,” Pathophysiology, vol. 13, no. 3, pp. 129–142, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. P. D. N'Guessan, F. Riediger, K. Vardarova et al., “Statins control oxidized ldl-mediated histone modifications and gene expression in cultured human endothelial cells,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 29, no. 3, pp. 380–386, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. M. M. Kavurma, N. Figg, M. R. Bennett, J. Mercer, L. M. Khachigian, and T. D. Uttlewood, “Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment,” Biochemical Journal, vol. 407, no. 1, pp. 79–87, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  42. C. P. Hodgkinson, R. C. Laxton, K. Patel, and S. Ye, “Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 12, pp. 2275–2281, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  43. E. Dragomir and M. Simionescu, “Monocyte chemoattractant protein-1—a major contributor to the inflammatory process associated with diabetes,” Archives of Physiology and Biochemistry, vol. 112, no. 4-5, pp. 239–244, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  44. J.-H. Xue, Z. Yuan, Y. Wu et al., “High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance,” Cardiovascular Research, vol. 86, no. 1, pp. 141–150, 2010. View at Publisher · View at Google Scholar · View at PubMed
  45. A. El-Osta, D. Brasacchio, D. Yao et al., “Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia,” Journal of Experimental Medicine, vol. 205, no. 10, pp. 2409–2417, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  46. L. M. Villeneuve, M. A. Reddy, L. L. Lanting, M. Wang, L. Meng, and R. Natarajan, “Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 26, pp. 9047–9052, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  47. M. O. Laukkanen, S. Mannermaa, M. O. Hiltunen et al., “Local hypomethylation in atherosclerosis found in rabbit ec-sod gene,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 19, no. 9, pp. 2171–2178, 1999. View at Google Scholar · View at Scopus
  48. M. O. Hiltunen and S. Ylä-Herttuala, “DNA methylation, smooth muscle cells, and atherogenesis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 10, pp. 1750–1753, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  49. G. Lund, L. Andersson, M. Lauria et al., “DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E,” Journal of Biological Chemistry, vol. 279, no. 28, pp. 29147–29154, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  50. J. Kim, J. Y. Kim, K. S. Song et al., “Epigenetic changes in estrogen receptor β gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence,” Biochimica et Biophysica Acta, vol. 1772, no. 1, pp. 72–80, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  51. J.-H. Choi, K.-H. Nam, J. Kim et al., “Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 11, pp. 2404–2409, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  52. X. Kong, M. Fang, P. Li, F. Fang, and Y. Xu, “HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells,” Journal of Molecular and Cellular Cardiology, vol. 46, no. 3, pp. 292–299, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  53. A. Zampetaki, L. Zeng, A. Margariti et al., “Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow,” Circulation, vol. 121, no. 1, pp. 132–142, 2010. View at Publisher · View at Google Scholar · View at PubMed
  54. K. Inoue, M. Kobayashi, K. Yano et al., “Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 12, pp. 2652–2659, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  55. W. Wang, C. H. Ha, B. S. Jhun, C. Wong, M. K. Jain, and Z.-G. Jin, “Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS,” Blood, vol. 115, no. 14, pp. 2971–2979, 2010. View at Publisher · View at Google Scholar · View at PubMed
  56. G. B. Atkins, Y. Wang, G. H. Mahabeleshwar et al., “Hemizygous deficiency of krüppel-like factor 2 augments experimental atherosclerosis,” Circulation Research, vol. 103, no. 7, pp. 690–693, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus