Figure 1: Activation of the renin-angiotensin-aldosterone system due to accumulation of cardiovascular risk factors causes imbalance between nitric oxide (NO) bioavailability and oxidative stress, leading to vascular inflammation. This upstream signaling exacerbates cardiorenal syndrome and evokes cardiovascular events. Statins ameliorate not only the serum lipid profile but also oxidative stress, NO bioavailability, and vascular inflammation by their pleiotropic effects.