Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation

Table 1

Endogenous and synthetic ligands for PPAR-γ and genes for PPAR-γ related coactivator.

Ligands for PPAR-𝛾		Genes for PPAR-𝛾 related co-activator
Endogenous ligands	Synthetic ligands
Unsaturated fatty acids	Rosiglitazone	CBP/p300
15-deoxy-Δ^12, 14-prostaglandin J2	Pioglitazone	SRC-1
15-HETE	Troglitazone	SRC-2
9-HODE	Ciglitazone	SRC-3
13-HODE	Tyrosine derivatives	PGC-1𝛼
Oxidized LDL	Farglitazar	PGC-1𝛽
	GW7845	PBP
		PRIP
		PRIC285
		BAF60c

BAF60c: BRG1/Brm-associated factor of 60 kDA subunit of c; CBP: cyclic-AMP responsive element binding protein (CREB)-binding protein; HETE: hydroxyeicosatetraenoic acid; HODE: hydroxyoctadecadienoic acid; LDL: low-density lipoprotein; PBP: PPAR-binding protein; PGC: PPAR-γ coactivator; PPAR: peroxisome proliferator-activated receptor; PRIC: PPAR-α-interacting cofactor; PRIP: PPAR interacting protein; SRC: steroid receptor coactivator.