Dual AAV/IL-10 Plus STAT3 Anti-Inflammatory Gene Delivery Lowers Atherosclerosis in LDLR KO Mice, but without Increased Benefit
Figure 3
Expression of the delivered hSTAT3 and IL-10. Relative expression of hSTAT3 (a) and IL-10 (b) genes by real-time quantitative PCR from aorta of 3 mice in each group. For qRT-PCR the quantity of RNA for each gene was normalized to GAPDH in the same sample. Data shown are mean ± SE. (c) shows the levels of total cholesterol. Note that cholesterol levels of the hSTAT3-plus-hIL-10-treated animals had significantly higher cholesterol levels than animals treated with individual genes. (d) shows the animal weights at the end of the experiment. The key at the bottom is used for both panels (c) and (d).
