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International Journal of Vascular Medicine
Volume 2012, Article ID 579531, 8 pages
http://dx.doi.org/10.1155/2012/579531
Clinical Study

Carotid Velocities Determine Cerebral Blood Flow Deficits in Elderly Men with Carotid Stenosis <50%

1Division of Geriatric Medicine, Department of Health Sciences, Skane University Hospital in Malmö, Lund University, 205 02 Malmö, Sweden
2Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Sciences, Skane University Hospital in Malmö, Lund University, 205 02 Malmö, Sweden

Received 1 October 2011; Revised 29 March 2012; Accepted 17 April 2012

Academic Editor: Mario Zuccarello

Copyright © 2012 Arkadiusz Siennicki-Lantz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To examine if mild carotid stenosis correlates with silent vascular brain changes, we studied a prospective population-based cohort “Men born in 1914.” Data from followups at ages 68 and 81, have been used. Carotid ultrasound was performed at age 81, and cerebral blood flow (CBF) was measured with SPECT at age 82. Out of 123 stroke-free patients, carotid stenosis <50% was observed in 94% in the right and 89% in the left internal carotid arteries (ICAs). In these subjects, Peak Systolic Velocities in ICA correlated negatively with CBF in a majority of several brain areas, especially in mesial temporal area. Results were limited to normotensive until their seventies, who developed late-onset hypertension with a subsequent blood pressure, pulse pressure, and ankle-brachial index growth. Elderly with asymptomatic carotid stenosis <50% and peak systolic velocities in ICA 0.7–1.3 m/s, should be offered an intensified pharmacotherapy to prevent stroke or silent cerebrovascular events.