International Journal of Vascular Medicine / 2012 / Article / Fig 1

Review Article

Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes

Figure 1

Under basal conditions, eNOS is kept in a “less active” state by binding to Cav-1. Activation of eNOS occurs by stimuli, (sheer stress, agonists such as acetylcholine, Ach), which causes an increase in intracellular Ca2+ and subsequent recruitment of cofactors and phosphorylation of the enzyme at S1177. Following which, eNOS is dissociated from Cav-1 and efficient EDNO production occurs. CaM: calmodulin; hsp90: heat shock protein 90.

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