Cell-to-cell communication. ECs are involved in cell-to-cell communication. Schematic representation of three reported communications is shown. (a) ECs-derived apoptotic bodies are transferred to recipient ECs. These apoptotic bodies contain miR-126 that suppress RGS16 expression, enabling CXCR4 to induce CXCL12 production. miR-126 can suppress SPRED1 and VCAM-1 expressions. (b) Shear stress stimulated ECs released miR-143/145 enriched microvesicles, which are transferred into VSMCs. (c) miR-150 is selectively loaded into monocyte derived microvesicles. These microvesicles are transferred to ECs and inhibit c-Myb expression in ECs.
