TY - JOUR A2 - Illig, Karl A. AU - Jaroslav, Pelisek AU - Christian, Reeps AU - Stefan, Ockert AU - Alexander, Zimmermann AU - Zepper, Peter AU - Holger, Poppert AU - Hans-Henning, Eckstein PY - 2012 DA - 2012/03/15 TI - Evaluation of Serum Biomarkers for Patients at Increased Risk of Stroke SP - 906954 VL - 2012 AB - Early recognition of vulnerable patients is an important issue for stroke prevention. In our study, a multiscore analysis of various biomarkers was performed to evaluate its superiority over the analysis of single factors. Study subjects (n=110) were divided into four groups: asymptomatic patients with stable (n=25) and unstable (n=36) plaques and symptomatic patients with stable (n=13) and unstable (n=36) plaques. Serum levels of MMP-1, -2, -3, -7, -8, -9, TIMP-1, -2, TNF-α, IL-1b, and IL-6, -8, -10, -12 were measured. Multi-score analysis was performed using multiple receiver operating characteristics (ROC) and determination of appropriate cutoff values. Significant differences between the groups were observed for MMP-1, -7, -9 and TIMP-1 in serum of the study subjects (P<0.05). Multiple biomarker analysis led to a significant increase in the AUC (area under curve). In case of plaque instability, positive predictive value (PPV) for up to 86.4% could be correctly associated with vulnerable plaques. Thus, multiscore analysis might be preferable than the use of single biomarkers. SN - 2090-2824 UR - https://doi.org/10.1155/2012/906954 DO - 10.1155/2012/906954 JF - International Journal of Vascular Medicine PB - Hindawi Publishing Corporation KW - ER -