The Oxidative State of Chylomicron Remnants Influences Their Modulation of Human Monocyte Activation
Uptake of native, oxidised, and probucol treated CRLP by primary human blood monocytes. Monocytes were incubated with CRLP at 37°C for 24 h before cytospin fixation and oil Red O staining. (a) Representative images (captured at magnification ×40 and enlarged). (b) Volocity quantitation (pixel count analysis) from monocyte isolations. Approximately, 700 cells were examined for each condition. C15/C30 control equivalent volume to 15/30 μg/mL cholesterol, N15/N30, CRLP at 15/30 μg/mL cholesterol, O15/O30 oxCRLP at 15/30 μg/mL cholesterol, P15/P30 pCRLP at 15/30 μg/mL cholesterol. **, *** analysis by one-way ANOVA and Bonferroni’s posttest.
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