Vascular Reactivity Concerning Orthosiphon stamineus Benth-Mediated Antihypertensive in Aortic Rings of Spontaneously Hypertensive Rats

Figure 4

ACh-induced relaxation responses of aortic rings precontracted with PE (1 µM) in the presence of indomethacin (10 μM) in control (vehicle) (a), losartan (10 mg/kg) (b), WOS (1000 mg/kg) (c), and WMOS (1000 mg/kg) (d). Responses to ACh are expressed as percentage of relaxation. Values are mean ± SEM of 5 to 6 SHRs in each group. *Denotes 𝑃<0.05 compared to ACh without indomethacin (■).

(a)

(b)

(c)

(d)