Table of Contents Author Guidelines Submit a Manuscript
International Journal of Vascular Medicine
Volume 2013, Article ID 543141, 10 pages
http://dx.doi.org/10.1155/2013/543141
Research Article

Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease: A Comparative Study Involving Different Biological Agents

1Department of Pathology, Nippon Medical School, 1-1-5 Bunkyo-ku, Sendagi, Tokyo 113-8603, Japan
2Department of Pediatrics, Nippon Medical School, 1-1-5 Bunkyo-ku, Sendagi, Tokyo 113-8603, Japan
3Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0355, Japan

Received 20 December 2012; Accepted 23 February 2013

Academic Editor: John A. Kern

Copyright © 2013 Ryuji Ohashi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Kawasaki, F. Kosaki, S. Okawa, I. Shigematsu, and H. Yanagawa, “A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan,” Pediatrics, vol. 54, no. 3, pp. 271–276, 1974. View at Google Scholar · View at Scopus
  2. R. Fukazawa, E. Ikegam, M. Watanabe et al., “Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence,” Circulation Journal, vol. 71, no. 5, pp. 709–715, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Ogawa, R. Fukazawa, T. Ohkubo et al., “Silent myocardial ischemia in Kawasaki disease: evaluation of percutaneous transluminal coronary angioplasty by dobutamine stress testing,” Circulation, vol. 96, no. 10, pp. 3384–3389, 1997. View at Google Scholar · View at Scopus
  4. D. Y. M. Leung, H. C. Meissner, S. T. Shulman et al., “Prevalence of superantigen-secreting bacteria in patients with Kawasaki disease,” Journal of Pediatrics, vol. 140, no. 6, pp. 742–746, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Furusho, T. Kamiya, and H. Nakano, “High-dose intravenous gammaglobulin for Kawasaki disease,” The Lancet, vol. 2, no. 8411, pp. 1055–1058, 1984. View at Google Scholar · View at Scopus
  6. J. W. Newburger, M. Takahashi, and J. C. Burns, “The treatment of Kawasaki syndrome with intravenous gamma globulin,” The New England Journal of Medicine, vol. 315, no. 6, pp. 341–347, 1986. View at Google Scholar · View at Scopus
  7. J. W. Newburger, M. Takahashi, M. A. Gerber et al., “Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the committee on rheumatic fever, endocarditis, and Kawasaki disease, council on cardiovascular disease in the young, American Heart Association,” Pediatrics, vol. 114, no. 6, pp. 1708–1733, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. D. A. Wright, J. W. Newburger, A. Baker, and R. P. Sundel, “Treatment of immune globulin-resistant Kawasaki disease with pulsed doses of corticosteroids,” Journal of Pediatrics, vol. 128, no. 1, pp. 146–149, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Adachi, H. Sakaguchi, T. Kuwahara, Y. Uchida, T. Fukao, and N. Kondo, “High regression rate of coronary aneurysms developed in patients with immune Globulin-Resistant Kawasaki disease treated with steroid pulse therapy,” Tohoku Journal of Experimental Medicine, vol. 220, no. 4, pp. 285–290, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Jibiki, I. Kato, T. Shiohama, K. Abe, S. Anzai, N. Takeda et al., “Intravenous immune globulin plus corticosteroids in refractory Kawasaki disease,” Pediatrics International, vol. 53, no. 5, pp. 729–735, 2011. View at Google Scholar
  11. V. Raman, J. Kim, A. Sharkey, and T. Chatila, “Response of refractory Kawasaki disease to pulse steroid and cyclosporin a therapy,” Pediatric Infectious Disease Journal, vol. 20, no. 6, pp. 635–637, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. C. A. Wallace, J. W. French, S. J. Kahn, and D. D. Sherry, “Initial intravenous gammaglobulin treatment failure in Kawasaki disease,” Pediatrics, vol. 105, no. 6, article E78, 2000. View at Google Scholar · View at Scopus
  13. M. Mori, T. Imagawa, S. Katakura et al., “Efficacy of plasma exchange therapy for Kawasaki disease intractable to intravenous gamma-globulin,” Modern Rheumatology, vol. 14, no. 1, pp. 43–47, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Kobayashi, T. Saji, T. Otani, K. Takeuchi, T. Nakamura, H. Arakawa et al., “Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial,” The Lancet, vol. 379, pp. 1613–1620, 2012. View at Google Scholar
  15. Y. Nakamura, M. Yashiro, R. Uehara, A. Sadakane, S. Tsuboi, Y. Aoyama et al., “Epidemiologic features of Kawasaki disease in Japan: results of the 2009–2010 nationwide survey,” Journal of Epidemiology, vol. 22, no. 3, pp. 216–221, 2012. View at Google Scholar
  16. T. Matsubara, T. Ichiyama, and S. Furukawa, “Immunological profile of peripheral blood lymphocytes and monocytes/macrophages in Kawasaki disease,” Clinical and Experimental Immunology, vol. 141, no. 3, pp. 381–387, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Gupta, G. J. Noel, M. Schaefer, D. Friedman, J. Bussel, and R. Johann-Liang, “Cytokine modulation with immune γ-globulin in peripheral blood of normal children and its implications in Kawasaki disease treatment,” Journal of Clinical Immunology, vol. 21, no. 3, pp. 193–199, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. D. S. Kim, H. K. Lee, G. W. Noh, S. I. Lee, and K. Y. Lee, “Increased serum Interleukin-10 level in Kawasaki disease,” Yonsei Medical Journal, vol. 37, no. 2, pp. 125–130, 1996. View at Google Scholar · View at Scopus
  19. S. Furukawa, T. Matsubara, Y. Umezawa, K. Okumara, and K. Yabuta, “Serum levels of p60 soluble tumor necrosis factor receptor during acute Kawasaki disease,” Journal of Pediatrics, vol. 124, no. 5, pp. 721–725, 1994. View at Publisher · View at Google Scholar · View at Scopus
  20. D. S. Kim and K. Y. Lee, “Serum soluble E-selectin levels in kawasaki disease,” Scandinavian Journal of Rheumatology, vol. 23, no. 5, pp. 283–286, 1994. View at Google Scholar · View at Scopus
  21. J. S. Hui-Yuen, T. T. Duong, and R. S. M. Yeung, “TNF-α is necessary for induction of coronary artery inflammation and aneurysm formation in an animal model of Kawasaki disease,” Journal of Immunology, vol. 176, no. 10, pp. 6294–6301, 2006. View at Google Scholar · View at Scopus
  22. N. F. Choueiter, A. K. Olson, D. D. Shen, and M. A. Portman, “Prospective open-label trial of etanercept as adjunctive therapy for kawasaki disease,” Journal of Pediatrics, vol. 157, no. 6, pp. 960.e1–966.e1, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. M. B. Son, K. Gauvreau, J. C. Burns et al., “Infliximab for intravenous immunoglobulin resistance in Kawasaki disease: a retrospective study,” Journal of Pediatrics, vol. 158, no. 4, pp. 644.e1–649.e1, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Nagi-Miura, T. Harada, H. Shinohara et al., “Lethal and severe coronary arteritis in DBA/2 mice induced by fungal pathogen, CAWS, Candida albicans water-soluble fraction,” Atherosclerosis, vol. 186, no. 2, pp. 310–320, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Hirata, K. I. Ishibashi, T. Usui, J. Yoshioka, S. Hata, Y. Adachi et al., “A model of left ventricular dysfunction complicated by CAWS arteritis in DBA/2 mice,” International Journal of Vascular Medicine, vol. 2012, Article ID 570297, 9 pages, 2012. View at Publisher · View at Google Scholar
  26. M. Uchiyama, N. Ohno, N. N. Miura et al., “Chemical and immunochemical characterization of limulus factor G-activating substance of Candida spp.,” FEMS Immunology and Medical Microbiology, vol. 24, no. 4, pp. 411–420, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Takahashi, T. Oharaseki, Y. Yokouchi et al., “Administration of human immunoglobulin suppresses development of murine systemic vasculitis induced with Candida albicans water-soluble fraction: an animal model of Kawasaki disease,” Modern Rheumatology, vol. 20, no. 2, pp. 160–167, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. B. A. Lang, E. D. Silverman, R. M. Laxer, and A. S. Lau, “Spontaneous tumor necrosis factor production in Kawasaki disease,” Journal of Pediatrics, vol. 115, no. 6, pp. 939–943, 1989. View at Publisher · View at Google Scholar · View at Scopus
  29. B. A. Eberhard, U. Andersson, R. M. Laxer, V. Rose, and E. D. Silverman, “Evaluation of the cytokine response in Kawasaki disease,” Pediatric Infectious Disease Journal, vol. 14, no. 3, pp. 199–203, 1995. View at Google Scholar · View at Scopus
  30. T. Jibiki, M. Terai, and Y. Kohno, “High concentrations of interleukin-8 and monocyte chemoattractant protein-1 in urine of patients with acute Kawasaki disease,” European Journal of Pediatrics, vol. 163, no. 12, pp. 749–750, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Oharaseki, Y. Kameoka, F. Kura, A. S. Persad, K. Suzuki, and S. Naoe, “Susceptibility loci to coronary arteritis in animal model of Kawasaki disease induced with Candida albicans-derived substances,” Microbiology and Immunology, vol. 49, no. 2, pp. 181–189, 2005. View at Google Scholar · View at Scopus
  32. K. Takahashi, T. Oharaseki, T. Nagao, Y. Yokouchi, H. Yamada, N. Nagi-Miura et al., “Mizoribine provides effective treatment of sequential histological change of arteritis and reduction of inflammatory cytokines and chemokines in an animal model of Kawasaki disease,” Pediatric Rheumatology Online Journal, vol. 9, no. 1, p. 30, 2011. View at Google Scholar
  33. T. Miethke, C. Wahl, K. Heeg, B. Echtenacher, P. H. Krammer, and H. Wagner, “T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor,” Journal of Experimental Medicine, vol. 175, no. 1, pp. 91–98, 1992. View at Publisher · View at Google Scholar · View at Scopus
  34. J. S. Pober, “Endothelial activation: intracellular signaling pathways,” Arthritis Research & Therapy, vol. 4, supplement 3, pp. S109–S116, 2002. View at Google Scholar
  35. K. Selmaj, A. Walczak, M. Mycko, T. Berkowicz, T. Kohno, and C. S. Raine, “Suppression of experimental autoimmune encephalomyelitis with a TNF binding protein (TNFbp) correlates with down-regulation of VCAM-1/VLA-4,” European Journal of Immunology, vol. 28, no. 6, pp. 2035–2044, 1998. View at Google Scholar
  36. J. R. O'Dell, “Anticytokine therapy—a new era in the treatment of rheumatoid arthritis?” The New England Journal of Medicine, vol. 340, no. 4, pp. 310–312, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. K. Takahashi, T. Oharaseki, S. Naoe, M. Wakayama, and Y. Yokouchi, “Neutrophilic involvement in the damage to coronary arteries in acute stage of Kawasaki disease,” Pediatrics International, vol. 47, no. 3, pp. 305–310, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Takahashi, T. Oharaseki, M. Wakayama, Y. Yokouchi, S. Naoe, and H. Murata, “Histopathological features of murine systemic vasculitis caused by Candida albicans extract—an animal model of Kawasaki Disease,” Inflammation Research, vol. 53, no. 2, pp. 72–77, 2004. View at Publisher · View at Google Scholar · View at Scopus
  39. N. Hirata, K. I. Ishibashi, S. Ohta et al., “Histopathological examination and analysis of mortality in DBA/2 mouse vasculitis induced with CAWS, a water-soluble extracellular polysaccharide fraction obtained from Candida albicans,” Yakugaku Zasshi, vol. 126, no. 8, pp. 643–650, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Kato, S. Koike, and T. Yokoyama, “Kawasaki disease: effect of treatment on coronary artery involvement,” Pediatrics, vol. 63, no. 2, pp. 175–179, 1979. View at Google Scholar · View at Scopus
  41. A. C. Wooditch and S. C. Aronoff, “Effect of initial corticosteroid therapy on coronary artery aneurysm formation in Kawasaki disease: a meta-analysis of 862 children,” Pediatrics, vol. 116, no. 4, pp. 989–995, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. Y. Inoue, Y. Okada, M. Shinohara et al., “A multicenter prospective randomized trial of corticosteroids in primary therapy for Kawasaki disease: clinical course and coronary artery outcome,” Journal of Pediatrics, vol. 149, no. 3, pp. 336.e1–341.e1, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Ogata, Y. Ogihara, T. Honda, S. Kon, K. Akiyama, and M. Ishii, “Corticosteroid pulse combination therapy for refractory Kawasaki disease: a randomized trial,” Pediatrics, vol. 129, no. 1, pp. e17–e23, 2012. View at Google Scholar