Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease: A Comparative Study Involving Different Biological Agents
Proinflammatory cytokine levels in plasma. At 2 weeks, plasma levels of IL-13, IL-17, KC, and TNF- were increased in the CAWS group, compared to negative control group. KC was suppressed by all the drugs tested, and IL-17 was reduced by etanercept and methylprednisolone treatment. At 4 weeks, the increased levels of IL-13, IL-17, and TNF-α persisted in the CAWS group with an increase in IL-6 and IL-12 levels. Etanercept significantly suppressed the levels of IL-6, IL-12, IL-13, and TNF-, whereas cyclosporine-A reduced IL-13, IL-17, and TNF-α levels.