Research Article
Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease: A Comparative Study Involving Different Biological Agents
Table 2
Proinflammatory cytokine levels in plasma. At 2 weeks, plasma levels of IL-13, IL-17, KC, and TNF- were increased in the CAWS group, compared to negative control group. KC was suppressed by all the drugs tested, and IL-17 was reduced by etanercept and methylprednisolone treatment. At 4 weeks, the increased levels of IL-13, IL-17, and TNF-α persisted in the CAWS group with an increase in IL-6 and IL-12 levels. Etanercept significantly suppressed the levels of IL-6, IL-12, IL-13, and TNF-, whereas cyclosporine-A reduced IL-13, IL-17, and TNF-α levels.
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versus Con. versus CAWS. versus CAWS. |