Association between Thrombophilia and the Post-Thrombotic Syndrome

Table 1

Included studies in deep vein thrombosis patients.

Reference	Author/year	Type of patient	Number of patients included	Thrombophilias assessed	𝑁 (%) with PTS	Criteria for PTS diagnosis
[24]	Prandoni et al., 1996	DVT	355	LAC, PC, PS, AT	99 (28)	Villalta
[25]	Prandoni et al., 1997	DVT	528	LAC, PC, PS, AT	119 (22.5)	Villalta
[26]	Prandoni et al., 2004	DVT	180	FVL, PTM, LAC, PC, PS	23 (25.6) patients; 44 (48.9) controls	Villalta
[27]	Schulman et al., 2006	DVT	545	FVL, PTM, APL	306 (56.3)	CEAP
[28]	Stain et al., 2005	DVT	406	FVIII, FVL, PTM	176 (43.3)	CEAP
[29]	Tick et al., 2008	DVT	1668	FVL, PTM	417 (25)	Modified Villalta
[30]	Biguzzi et al., 1998	DVT	51	FVL, LAC, PC, PS, AT	32 (63)	CEAP
[31]	Kahn et al., 2005	DVT	145	FVL, PTM	54 (37.2)	Villalta
[32]	Kahn et al., 2008	DVT	387	FVL, PTM	102 (40)	Villalta
[33]	Spiezia et al., 2010	DVT	530	FVL, PTM, LAC, PC, PS, AT	172 (32.5)	Villalta
[34]	Bittar et al., 2012	DVT	55	FVIII	31 (56.3)	CEAP

FVL: factor V Leiden, PTM: prothrombin G20210A, APC res: activated protein C resistance, LAC: lupus anticoagulant, APL: antiphospholipid antibodies, PC: protein C deficiency, PS: protein S deficiency, AT: antithrombin deficiency, FVIII: coagulation factor VIII, DVT: deep vein thrombosis, CVU: chronic venous ulcer, PTS: postthrombotic syndrome, and CEAP: clinical, aetiological, anatomical, and pathological classification.