Chronic NaHS Treatment Is Vasoprotective in High-Fat-Fed ApoE^−/− Mice

Figure 1

Systolic blood pressure (SBP) measured by the tail-cuff method in WT (open bar) and fat-fed ApoE^−/− mice (shaded bar). Fat-fed ApoE^−/− mice had a significantly higher SBP than age matched WT controls. SBP was significantly reduced in fat-fed ApoE^−/− mice treated with either 10 or 100 μmol/kg/day NaHS. Treatment with PPG 30 mg/kg/day had no effect on SBP. ^#𝑃<0.05, 𝑡-test WT versus fat-fed ApoE^−/− mice, ^∗∗∗𝑃<0.001, ANOVA, untreated versus treated, 𝑛=6--9.