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International Journal of Vascular Medicine
Volume 2014, Article ID 845960, 8 pages
http://dx.doi.org/10.1155/2014/845960
Research Article

Investigation of Serum Oxidized Low-Density Lipoprotein IgG Levels in Patients with Angiographically Defined Coronary Artery Disease

1Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Cardiology, Mashhad University of Medical Sciences, Mashhad, Iran
3Student Research Committee, Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran
5Health Sciences Research Center, Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
6Department of Clinical Biochemistry, Tehran University of Medical Sciences, Tehran, Iran
7Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Received 14 July 2013; Revised 22 September 2013; Accepted 6 October 2013; Published 3 February 2014

Academic Editor: Karlheinz Peter

Copyright © 2014 Mohsen Moohebati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It has been suggested that antioxidized low-density lipoprotein (anti-oxLDL) antibodies play a role in the pathogenesis of atherosclerosis. The aim of this study was to measure serum ox-LDL IgG levels in 31 patients with angiographically defined coronary artery disease (CAD) (≥50% stenosis in at least one major coronary artery; CAD+ group) and compare these levels with those of 32 subjects with <50% coronary stenosis (CAD group) and 24 healthy age- and sex-matched controls using ELISA. We did not find any significant difference between CAD+, CAD, and control groups in regard to oxLDL IgG levels ( ). Serum oxLDL IgG levels did not differ between 1VD (one vessel disease), 2VD (2 vessels disease), and 3VD (3 vessels disease) subgroups of CAD+ patients ( ). Serum anti-oxLDL titers were only significantly correlated with LDL-C in the CAD+ group ( ) and waist and hip circumference ( and , resp.) in the CAD group. In stepwise regression analysis, none of the conventional cardiovascular risk factors was associated with serum ox-LDL IgG levels. The present results suggest that serum levels of ox-LDL IgG are neither associated with the presence and severity of CAD nor with the conventional cardiovascular risk factors.