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International Journal of Vascular Medicine
Volume 2014, Article ID 859726, 5 pages
http://dx.doi.org/10.1155/2014/859726
Review Article

Influence of Acquired and Genetic Risk Factors on the Prevention, Management, and Treatment of Thromboembolic Disease

Department of Vascular Surgery, Saint George Hospital, University Medical Center, University of Balamand, Youssef Sursock Street, P.O. Box 166378, Achrafieh, Beirut 1100 2807, Lebanon

Received 22 December 2013; Accepted 11 June 2014; Published 26 June 2014

Academic Editor: Robert M. Schainfeld

Copyright © 2014 Raghid Kreidy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Hirsh and J. Hoak, “Management of deep vein thrombosis and pulmonary embolism: a statement for healthcare professionals,” Circulation, vol. 93, no. 12, pp. 2212–2245, 1996. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Avorn and W. C. Winkelmayer, “Comparing the costs, risks, and benefits of competing strategies for the primary prevention of venous thromboembolism,” Circulation, vol. 110, supplement 1, pp. IV25–IV32, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. M. McGuckin, R. Waterman, J. Brooks et al., “Validation of venous leg ulcer guidelines in the United States and United Kingdom,” American Journal of Surgery, vol. 183, no. 2, pp. 132–137, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Kreidy and N. I. Hakime, “Deep vein thrombosis of the lower extremities: a benign disease?” Chirurgia, vol. 22, no. 3, pp. 143–147, 2009. View at Google Scholar · View at Scopus
  5. M. Montagnana, E. J. Favaloro, M. Franchini, G. C. Guidi, and G. Lippi, “The role of ethnicity, age and gender in venous thromboembolism,” Journal of Thrombosis and Thrombolysis, vol. 29, no. 4, pp. 489–496, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. F. R. Rosendaal, “Venous thrombosis: a multicausal disease,” The Lancet, vol. 353, no. 9159, pp. 1167–1173, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. P. D. Stein, R. D. Hull, F. Kayali, W. A. Ghali, A. K. Alshab, and R. E. Olson, “Venous thromboembolism according to age: the impact of an aging population,” Archives of Internal Medicine, vol. 164, no. 20, pp. 2260–2265, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. I. A. Næss, S. C. Christiansen, P. Romundstad, S. C. Cannegieter, F. R. Rosendaal, and J. Hammerstrøm, “Incidence and mortality of venous thrombosis: a population-based study,” Journal of Thrombosis and Haemostasis, vol. 5, no. 4, pp. 692–699, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Kreidy, P. Salameh, and M. Waked, “Lower extremity venous thrombosis in patients younger than 50 years of age,” Vascular Health and Risk Management, vol. 8, no. 1, pp. 161–167, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Kreidy, “Venous thrombosis of lower extremities in young patients,” Phlebolymphology, vol. 20, no. 1, p. 30, 2012. View at Google Scholar
  11. R. Kreidy, “Underdiagnosed cause of lower extremity venous thrombosis in the young patient,” International Angiology, vol. 32, supplement 1, p. 66, 2013. View at Google Scholar
  12. J. G. Schneider, M. V. Eynatten, K. A. Dugi, M. Duex, and P. P. Nawroth, “Recurrent deep venous thrombosis caused by congenital interruption of the inferior vena cava and heterozygous factor V Leiden mutation,” Journal of Internal Medicine, vol. 252, no. 3, pp. 276–280, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Alikhan, A. T. Cohen, S. Combe et al., “Risk factors for venous thromboembolism in hospitalized patients with acute medical illness: analysis of the MEDENOX Study,” Archives of Internal Medicine, vol. 164, no. 9, pp. 963–968, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Kreidy, M. Waked, E. Stephan et al., “Acquired and genetic risk factors for deep vein thrombosis of lower extremities among Lebanese patients,” Le Journal Médical Libanais, vol. 60, no. 1, pp. 24–29, 2012. View at Google Scholar · View at Scopus
  15. R. Kreidy, E. Stephan, P. Salameh, and M. Waked, “Value of venous color flow duplex as initial screening test for geriatric inpatients with clinically suspected pulmonary embolism,” Vascular Health and Risk Management, vol. 7, pp. 585–589, 2011. View at Google Scholar · View at Scopus
  16. R. Kreidy, E. Stephan, P. Salameh, and M. Waked, “Lower extremity venous thrombosis in the elderly patient,” International Angiology, vol. 32, supplement 1, p. 53, 2013. View at Google Scholar
  17. J. A. Heit, “Venous thromboembolism: disease burden, outcomes and risk factors,” Journal of Thrombosis and Haemostasis, vol. 3, no. 8, pp. 1611–1617, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. R. H. White, H. Zhou, and P. S. Romano, “Incidence of symptomatic venous thromboembolism after different elective or urgent surgical procedures,” Thrombosis and Haemostasis, vol. 90, no. 3, pp. 446–455, 2003. View at Google Scholar · View at Scopus
  19. G. H. Guyatt, E. A. Akl, M. Crowther, D. D. Gutterman, and H. J. Schünemann, “Executive summary: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines,” Chest, vol. 141, no. 2, pp. 7S–47S, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Marchiori, L. Mosena, M. H. Prins, and P. Prandoni, “The risk of recurrent venous thromboembolism among heterozygous carriers of factor V Leiden or prothrombin G20210A mutation. A systematic review of prospective studies,” Haematologica, vol. 92, no. 8, pp. 1107–1114, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Oger, C. Leroyer, E. Le Moigne et al., “The value of a risk factor analysis in clinically suspected deep venous thrombosis,” Respiration, vol. 64, no. 5, pp. 326–330, 1997. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Chandra, E. Parisini, and D. Mozaffarian, “Meta-analysis: travel and risk for venous thromboembolism,” Annals of Internal Medicine, vol. 151, no. 3, pp. 180–190, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Cushman, “Inherited risk factors for venous thrombosis,” Hematology, vol. 2005, no. 1, pp. 452–457, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. I. Martinelli, V. de Stefano, E. Taioli, K. Paciaroni, E. Rossi, and P. M. Mannucci, “Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium,” Thrombosis and Haemostasis, vol. 87, no. 5, pp. 791–795, 2002. View at Google Scholar · View at Scopus
  25. S. M. Bates, “Management of pregnant women with thrombophilia or a history of venous thromboembolism,” Hematology/American Society of Hematology. Education Program, pp. 143–150, 2007. View at Google Scholar · View at Scopus
  26. K. A. Parsi, M. A. McGrath, and R. S. A. Lord, “Traveller's venous thromboembolism,” Cardiovascular Surgery, vol. 9, no. 2, pp. 157–158, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Kreidy, “Pathophysiology of post-thrombotic syndrome : the effect of recurrent venous thrombosis and inherited thrombophilia,” ISRN Vascular Medicine, vol. 2011, Article ID 513503, 4 pages, 2011. View at Publisher · View at Google Scholar
  28. R. Kreidy, “Contribution of recurrent venous thrombosis and inherited thrombophilia to the pathogenesis of postthrombotic syndrome,” Clinical Applied Thrombosis and Haemostasis, 2013. View at Google Scholar
  29. R. Kreidy and N. Irani-Hakime, “Is thrombophilia a major risk factor for deep vein thrombosis of the lower extremities among Lebanese patients?” Vascular Health and Risk Management, vol. 5, pp. 627–633, 2009. View at Google Scholar · View at Scopus
  30. S. Moll, “Thrombophilias—practical implications and testing caveats,” Journal of Thrombosis and Thrombolysis, vol. 21, no. 1, pp. 7–15, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. L. N. Roberts, R. K. Patel, and R. Arya, “Venous thromboembolism and ethnicity,” British Journal of Haematology, vol. 146, no. 4, pp. 369–383, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. W. H. Geerts, J. A. Heit, G. P. Clagett et al., “Prevention of venous thromboembolism,” Chest, vol. 119, no. 1, supplement, pp. 381S–175S, 2001. View at Google Scholar · View at Scopus
  33. H. Irani-Hakimeh, H. Tamim, R. Kreidy, and W. Y. Almawi, “The prevalence of factor V R506Q mutation-Leiden among apparently healthy Lebanese,” The American Journal of Hematology, vol. 65, no. 1, pp. 45–49, 2000. View at Google Scholar
  34. I. Aschka, V. Aumann, F. Bergmann et al., “Prevalence of factor V leiden in children with thrombo-embolism,” European Journal of Pediatrics, vol. 155, no. 12, pp. 1009–1014, 1996. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Kreidy, “Factor V-Leiden mutation: a common risk factor for venous thrombosis among Lebanese patients,” Thrombosis, vol. 2012, Article ID 380681, 4 pages, 2012. View at Publisher · View at Google Scholar
  36. S. R. Poort, F. R. Rosendaal, P. H. Reitsma, and R. M. Bertina, “A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis,” Blood, vol. 88, no. 10, pp. 3698–3703, 1996. View at Google Scholar · View at Scopus
  37. V. De Stefano, P. Chiusolo, K. Paciaroni, and G. Leone, “Epidemiology of factor V leiden: clinical implications,” Seminars in Thrombosis and Hemostasis, vol. 24, no. 4, pp. 367–379, 1998. View at Publisher · View at Google Scholar · View at Scopus
  38. G. Palareti, “Current criteria to determine the duration of anticoagulant therapy,” Recent Progress in Medicine, vol. 98, no. 12, pp. 603–606, 2007. View at Google Scholar · View at Scopus
  39. M. A. Crowther and J. G. Kelton, “Congenital thrombophilic states associated with venous thrombosis: a qualitative overview and proposed classification system,” Annals of Internal Medicine, vol. 138, no. 2, pp. 128–134, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. S. M. Naushad, M. N. J. Jamal, R. Angalena, C. K. Prasad, and A. R. R. Devi, “Hyperhomocysteinemia and the compound heterozygous state for methylene tetrahydrofolate reductase are independent risk factors for deep vein thrombosis among South Indians,” Blood Coagulation and Fibrinolysis, vol. 18, no. 2, pp. 113–117, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. I. Spiroski, S. Kedev, S. Antov et al., “Association of methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genetic polymorphisms with occlusive artery disease and deep venous thrombosis in Macedonians,” Croatian Medical Journal, vol. 49, no. 1, pp. 39–49, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. J. G. Ray, D. Shmorgun, and W. S. Chan, “Common C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of venous thromboembolism: Meta-analysis of 31 studies,” Pathophysiology of Haemostasis and Thrombosis, vol. 32, no. 2, pp. 51–58, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. N. Akar, E. Akar, R. Akçay, F. Avcu, A. Yalcin, and S. Cin, “Effect Of metylenetetrahydrofolate reductase 677 C-T, 1298 A-C, and 1317 T-C on factor V 1691 mutation in Turkish deep vein thrombosis patients,” Thrombosis Research, vol. 97, no. 3, pp. 163–167, 2000. View at Publisher · View at Google Scholar · View at Scopus
  44. G. S. Zaatari, Z. K. Otrock, A. S. Sabbagh, and R. A. R. Mahfouz, “Prevalence of factor V R2 (H1299R) polymorphism in the Lebanese population,” Pathology, vol. 38, no. 5, pp. 442–444, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. R. Kreidy, M. Waked, E. Stephan, I. Jureidini, and N. Irani-Hakime, “Contribution of factor V R 506 Q-Leiden , prothrombin G 20210 A and MTHFR C 677 T mutation to the genetic susceptibility of deep vein thrombosis of lower extremities. Is screening for factor V H 1299 R and MTHFR A 1298 C justified?” International Angiology, vol. 28, supplement 1, no. 4, pp. S123–S124, 2009. View at Google Scholar