Table of Contents Author Guidelines Submit a Manuscript
International Journal of Vascular Medicine
Volume 2014, Article ID 917271, 8 pages
http://dx.doi.org/10.1155/2014/917271
Research Article

Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction

1Research Center, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street East, Montreal, QC, Canada H1T 1C8
2Departments of Medicine and Pharmacology, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada
3Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
4The Kidney Research Center, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
5Palo Alto VA Health Care System, Stanford University, Palo Alto, CA, USA
6Cardiovascular Prevention and Rehabilitation Centre, Montreal Heart Institute, Montreal, QC, Canada
7Coordinating Center, Montreal Heart Institute, Montreal, QC, Canada
8Faculty of Pharmacy, Université de Montréal, Montreal, QC, Canada

Received 25 July 2013; Accepted 14 January 2014; Published 27 February 2014

Academic Editor: Robert M. Schainfeld

Copyright © 2014 Damien Vitiello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Puntawangkoon, D. W. Kitzman, S. B. Kritchevsky et al., “Reduced peripheral arterial blood flow with preserved cardiac output during submaximal bicycle exercise in elderly heart failure,” Journal of Cardiovascular Magnetic Resonance, vol. 11, no. 1, p. 48, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. P. S. Bhella, A. Prasad, K. Heinicke et al., “Abnormal haemodynamic response to exercise in heart failure with preserved ejection fraction,” European Journal of Heart Failure, vol. 13, no. 12, pp. 1296–1304, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Hollenberg and I. B. Tager, “Oxygen uptake efficiency slope: an index of exercise performance and cardiopulmonary reserve requiring only submaximal exercise,” Journal of the American College of Cardiology, vol. 36, no. 1, pp. 194–201, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Van Laethem, J. Bartunek, M. Goethals, P. Nellens, E. Andries, and M. Vanderheyden, “Oxygen uptake efficiency slope, a new submaximal parameter in evaluating exercise capacity in chronic heart failure patients,” American Heart Journal, vol. 149, no. 1, pp. 175–180, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. L. C. Davies, R. Wensel, P. Georgiadou et al., “Enhanced prognostic value from cardiopulmonary exercise testing in chronic heart failure by non-linear analysis: oxygen uptake efficiency slope,” European Heart Journal, vol. 27, no. 6, pp. 684–690, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Arena, P. Brubaker, B. Moore, and D. Kitzman, “The oxygen uptake efficiency slope is reduced in older patients with heart failure and a normal ejection fraction,” International Journal of Cardiology, vol. 144, no. 1, pp. 101–102, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. S. de Denus, J. Lavoie, A. Ducharme et al., “Differences in biomarkers in patients with heart failure with a reduced vs a preserved left ventricular ejection fraction,” Canadian Journal of Cardiology, vol. 28, no. 1, pp. 62–68, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Niethammer, M. Sieber, S. von Haehling et al., “Inflammatory pathways in patients with heart failure and preserved ejection fraction,” International Journal of Cardiology, vol. 129, no. 1, pp. 111–117, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Clark, M. Volterrani, J. W. Swan, D. Hue, J. Hooper, and A. J. S. Coats, “Leg blood flow, metabolism and exercise capacity in chronic stable heart failure,” International Journal of Cardiology, vol. 55, no. 2, pp. 127–135, 1996. View at Publisher · View at Google Scholar · View at Scopus
  10. M. J. Haykowsky, D. M. Herrington, P. H. Brubaker, T. M. Morgan, W. G. Hundley, and D. W. Kitzman, “Relationship of flow-mediated arterial dilation and exercise capacity in older patients with heart failure and preserved ejection fraction,” Journals of Gerontology A, vol. 68, no. 2, pp. 161–167, 2013. View at Publisher · View at Google Scholar
  11. W. G. Hundley, E. Bayram, C. A. Hamilton et al., “Leg flow-mediated arterial dilation in elderly patients with heart failure and normal left ventricular ejection fraction,” American Journal of Physiology, vol. 292, no. 3, pp. H1427–H1434, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. B. Meyer, D. Mörtl, K. Strecker et al., “Flow-mediated vasodilation predicts outcome in patients with chronic heart failure: comparison with B-type natriuretic peptide,” Journal of the American College of Cardiology, vol. 46, no. 6, pp. 1011–1018, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Myers, D. Walsh, N. Buchanan, P. McAuley, E. Bowes, and V. Froelicher, “Increase in blood lactate during ramp exercise: comparison of continuous and threshold models,” Medicine and Science in Sports and Exercise, vol. 26, no. 11, pp. 1413–1419, 1994. View at Google Scholar · View at Scopus
  14. E. Normandin, A. Nigam, P. Meyer et al., “Acute responses to intermittent and continuous exercise in heart failure patients,” Canadian Journal of Cardiology, vol. 29, no. 4, pp. 466–471, 2013. View at Publisher · View at Google Scholar
  15. R. Baba, M. Nagashima, M. Goto et al., “Oxygen uptake efficiency slope: a new index of cardiorespiratory functional reserve derived from the relation between oxygen uptake and minute ventilation during incremental exercise,” Journal of the American College of Cardiology, vol. 28, no. 6, pp. 1567–1572, 1996. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Virdis, M. F. Neves, F. Amiri, E. Viel, R. M. Touyz, and E. L. Schiffrin, “Spironolactone improves angiotensin-induced vascular changes and oxidative stress,” Hypertension, vol. 40, no. 4, pp. 504–510, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Harel, N. Olamaei, Q. Ngo, J. Dupuis, and P. Khairy, “Arterial flow measurements during reactive hyperemia using NIRS,” Physiological Measurement, vol. 29, no. 9, pp. 1033–1040, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. B. A. Borlaug, V. Melenovsky, S. D. Russell et al., “Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction,” Circulation, vol. 114, no. 20, pp. 2138–2147, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. T. T. Phan, K. Abozguia, G. Nallur Shivu et al., “Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency,” Journal of the American College of Cardiology, vol. 54, no. 5, pp. 402–409, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. T. T. Phan, G. N. Shivu, K. Abozguia et al., “Impaired heart rate recovery and chronotropic incompetence in patients with heart failure with preserved ejection fraction,” Circulation, vol. 3, no. 1, pp. 29–34, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Bishu, A. Deswal, H. H. Chen et al., “Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction,” American Heart Journal, vol. 164, no. 5, pp. 763–770, 2012. View at Publisher · View at Google Scholar
  22. A. Kalogeropoulos, V. Georgiopoulou, B. M. Psaty et al., “Inflammatory markers and incident heart failure risk in older adults. The health ABC (health, aging, and body composition) study,” Journal of the American College of Cardiology, vol. 55, no. 19, pp. 2129–2137, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. B. A. Borlaug, T. P. Olson, C. S. P. Lam et al., “Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction,” Journal of the American College of Cardiology, vol. 56, no. 11, pp. 845–854, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Tschöpe, M. Kašner, D. Westermann, R. Gaub, W. C. Poller, and H. Schultheiss, “The role of NT-proBNP in the diagnostics of isolated diastolic dysfunction: correlation with echocardiographic and invasive measurements,” European Heart Journal, vol. 26, no. 21, pp. 2277–2284, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. S. F. Mohammed, T. Ohtani, J. Korinek et al., “Mineralocorticoid accelerates transition to heart failure with preserved ejection fraction via ‘nongenomic effects’,” Circulation, vol. 122, no. 4, pp. 370–378, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Braunwald, “Medical progress: biomarkers in heart failure,” New England Journal of Medicine, vol. 358, no. 20, pp. 2094–2159, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Nagaset and J. F. Woessner Jr., “Matrix metalloproteinases,” Journal of Biological Chemistry, vol. 274, no. 31, pp. 21491–21494, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Cox, U. A. Hawkins, B. D. Hoit, and S. C. Tyagi, “Attenuation of oxidative stress and remodeling by cardiac inhibitor of metalloproteinase protein transfer,” Circulation, vol. 109, no. 17, pp. 2123–2128, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. J. R. Gage, G. Fonarow, M. Hamilton, M. Widawski, O. Martínez-Maza, and D. L. Vredevoe, “Beta blocker and angiotensin-converting enzyme inhibitor therapy is associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production in patients with chronic heart failure,” NeuroImmunoModulation, vol. 11, no. 3, pp. 173–180, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Zhang, Z. B. Popović, S. Bibevski et al., “Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing model,” Circulation, vol. 2, no. 6, pp. 692–699, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. N. Preumont, P. Unger, S. Goldman, and G. Berkenboom, “Effect of long-term angiotensin II type I receptor antagonism on peripheral and coronary vasomotion,” Cardiovascular Drugs and Therapy, vol. 18, no. 3, pp. 197–202, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Warnholtz, M. A. Ostad, T. Heitzer et al., “AT1-receptor blockade with irbesartan improves peripheral but not coronary endothelial dysfunction in patients with stable coronary artery disease,” Atherosclerosis, vol. 194, no. 2, pp. 439–445, 2007. View at Publisher · View at Google Scholar · View at Scopus